N-glycan glucose trimming of Spike

Stable Identifier
R-HSA-9694364
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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N-glycan glucose trimming of Spike
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N-glycan side chains on the unfolded SARS-CoV-2 spike protein get their terminal glucose moieties cleaved by ER glucosidases I and II, before folding. (Watanabe et al, 2020, Völker et al, 2002, Pelletier et al, 2000).
Literature References
PubMed ID Title Journal Year
32366695 Site-specific glycan analysis of the SARS-CoV-2 spike

Watanabe, Y, Crispin, M, Allen, JD, McLellan, JS, Wrapp, D

Science 2020
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glucan 1,3-alpha-glucosidase activity of ER alpha-glucosidases [endoplasmic reticulum lumen]

Physical Entity
ER alpha-glucosidases [endoplasmic reticulum lumen] (Homo sapiens)
Activity
glucan 1,3-alpha-glucosidase activity (GO:0033919)

Glc3Man9GlcNAc2 oligosaccharide glucosidase activity of MOGS [endoplasmic reticulum membrane]

Physical Entity
MOGS [endoplasmic reticulum membrane] (Homo sapiens)
Activity
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity (GO:0004573)
This event is regulated
Negatively by
Regulator
ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen] (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-07-22)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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