GalNAc is transferred onto 3a

Stable Identifier
R-HSA-9694438
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
Locations in the PathwayBrowser
General
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

A sialyltransferase adds a terminal sialic acid moiety to protein 3a with an O-linked glycosyl side chain. This glycosylated form later is associated with the virion (Oostra et al, 2006)

Literature References
PubMed ID Title Journal Year
16474139 Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M

Oostra, M, de Haan, CA, de Groot, RJ, Rottier, PJ

J. Virol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
polypeptide N-acetylgalactosaminyltransferase activity of GALNT1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Physical Entity
Activity
Inferred From
Disease
Name Identifier Synonyms
COVID-19 0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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