M protein gets N-glycosylated

Stable Identifier
R-HSA-9694525
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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M protein gets N-glycosylated
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This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Protein M is exclusively N-glycosylated at one asparagine by an unknown glycosyltransferase. However, further processing of N-linked glycans is prevented in infected cells. Both the glycosylated and nonglycosylated M is incorporated into the virion. In summary, glycosylation of M is neither a prerequisite for intra-cellular transport nor for recruitment into the virion (Voss et al, 2006).
Literature References
PubMed ID Title Journal Year
16442106 Characterization of severe acute respiratory syndrome coronavirus membrane protein

Eickmann, M, Voss, D, Kern, A, Lanzavecchia, A, Becker, S, Traggiai, E, Stadler, K

FEBS Lett. 2006
Participants
Input
Output
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as an event of
Inferred From
M protein gets N-glycosylated (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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