Protein 3a forms a homotetramer

Stable Identifier
R-HSA-9694662
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
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Protein 3a forms a homotetramer
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SARS-Cov-2 protein 3a can form homodimers and tetramers. Both dimer and tetramer show typical patterns of ion channels. Transport of sodium and potassium ions through this channel is long-lasting (Kern et al, 2020).
Literature References
PubMed ID Title Journal Year
32587976 Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs

Hoel, CM, Toso, DB, Sorum, B, Brohawn, SG, Sridharan, S, Remis, JP, Kern, DM

bioRxiv 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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