Maturation of protein 3a

Stable Identifier
R-HSA-9694719
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
ReviewStatus
5/5
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Maturation of protein 3a
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This COVID-19 pathway has been created by a combination of computational inference from SARS-CoV-1 data (https://reactome.org/documentation/inferred-events) and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Protein 3a is associated with protein M and is found in the virion, although its function in the structure seems non-essential. 3a is O-glycosylated and forms a homotetramer with porin function (Oostra et al, 2006; Lu et al, 2006)
Literature References
PubMed ID Title Journal Year
16894145 Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release

Deubel, V, Xu, K, Sun, B, Duan, S, Lu, W, Schwarz, W, Wong, CK, Du, L, Chen, J, Zheng, BJ

Proc. Natl. Acad. Sci. U.S.A. 2006
16474139 Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M

de Haan, CA, de Groot, RJ, Oostra, M, Rottier, PJ

J. Virol. 2006
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
viral protein processing (0019082)
Inferred From
Maturation of protein 3a (Homo sapiens)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2020-08-28)
Reviewed
Acencio, ML  (2020-09-09)
Created
Cook, J  (2020-07-07)
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