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Assembly of HCMV Procapsid
Stable Identifier
R-HSA-9698932
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
nucleoplasm
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Late Events (Homo sapiens)
Assembly of HCMV Procapsid (Homo sapiens)
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The procapsid shell is made up of major capsid proteins (MCP)-containing capsomeres, with six copies of MCP per hexon and five copies of MCP per penton. One of the 12 pentons in each capsid is composed entirely of portal protein (PORT), the UL104 protein, a self-assembling homododecamer. The PORT penton provides a channel for viral DNA encapsidation. Triplex (TRI) complex TRI1:TRI2 is added to stabilize hexons and pentons, and small capsid protein (SCP )decorates the outer capsid surface, interacting with MCP at hexon tips.
Before the capsid has aquired the genome, it is designated a B capsid. Three capsid forms accumulate in the nucleus of herpesvirus-infected cells: A capsids that lack both scaffold and packaged viral DNA, B capsids that contain scaffold but lack viral DNA, and C capsids, contains viral DNA in place of scaffold and probably represents nucleocapsids in the process of maturation.
Literature References
PubMed ID
Title
Journal
Year
Fields Virology
Knipe, DM
,
Howley, PM
2013
Participants
Input
x 955
MCP [nucleoplasm]
(Human cytomegalovirus)
pAP [nucleoplasm]
(Human cytomegalovirus)
pBR [nucleoplasm]
(Human cytomegalovirus)
x 960
SCP [nucleoplasm]
(Human cytomegalovirus)
x 320
TR2:TR1 [nucleoplasm]
(Human cytomegalovirus)
x 12
UL104 [nucleoplasm]
(Human cytomegalovirus)
x 960
UL132 [nucleoplasm]
(Human cytomegalovirus)
Output
HCMV B Capsid [viral capsid]
(Human cytomegalovirus)
Participates
as an event of
HCMV Late Events (Homo sapiens)
Disease
Name
Identifier
Synonyms
viral infectious disease
DOID:934
Viral disease, virus infection, virus infection
Authored
Gillespie, ME (2018-11-28)
Reviewed
Streblow, DN (2019-10-18)
Caposio, P (2019-10-18)
Created
Gillespie, ME (2019-02-12)
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