Active ALK binds FRS2

Stable Identifier
R-HSA-9700142
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Active ALK binds FRS2
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The adaptor protein FRS2 binds activated ALK as assessed with studies using full-length wild-type ALK as well as the NPM1-ALK fusion (Degoutin et al, 2007; Chikamori et al, 2007). Recruitment and activation of FRS2 does not depend on the juxtamembrane domain or any of the identified phosphotyrosine binding (PTB) NXXpY sites of ALK, and the binding site remains to be determined (Chikamori et al, 2007; Degoutin et al, 2007).
Literature References
PubMed ID Title Journal Year
17086210 Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation

Chikamori, M, Fujimoto, J, Tokai-Nishizumi, N, Yamamoto, T

Oncogene 2007
17274988 ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

Degoutin, J, Vigny, M, Gouzi, JY

FEBS Lett. 2007
Participants
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Inferred From
Active ALK binds Frs2 (Rattus norvegicus)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Turner, S  (2023-11-08)
Created
Rothfels, K  (2020-09-14)
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