Active ALK binds SRC

Stable Identifier
Reaction [binding]
Homo sapiens
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Based on studies with the oncogenic fusion protein NPM-ALK, SRC (and potentially other SRC-family members) binds to activated ALK receptor. Binding depends on tyrosine residue 1358 and ALK kinase activity, identifying pY1358 as the SRC-binding site (Cussac et al, 2004). SRC signaling downstream of ALK contributes to cellular proliferation (Cussac et al, 2004; reviewed in Chiarle et al, 2008; Palmer et al, 2009).

Literature References
PubMed ID Title Journal Year
19459784 Anaplastic lymphoma kinase: signalling in development and disease

Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B

Biochem. J. 2009
18097461 The anaplastic lymphoma kinase in the pathogenesis of cancer

Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C

Nat. Rev. Cancer 2008
14563642 Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity

Roche, S, Duyster, J, Greenland, C, Morris, SW, Delsol, G, Bai, RY, Payrastre, B, Allouche, M, Cussac, D

Blood 2004
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