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K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
Stable Identifier
R-HSA-9701028
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)
DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
UBXN1:K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Metalloprotease DUBs (Homo sapiens)
BRCA1-A complex deubiquitinates K63polyUb-histone H2A (Homo sapiens)
BRCA1-A Complex:Histone H2A [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
BRCA1-A Complex:K63polyUb-histone H2A [nucleoplasm] (Homo sapiens)
BRCA1-A Complex [nucleoplasm] (Homo sapiens)
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
Participants
components
K6PolyUb-BARD1 [nucleoplasm]
(Homo sapiens)
K6PolyUb-BRCA1 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
UBXN1:K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)
as an input of
UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)
as a member of
BRCA1:BARD1 [nucleoplasm] (Homo sapiens)
as an output of
BRCA1:BARD1 heterodimer autoubiquitinates (Homo sapiens)
Inferred To
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
(Bos taurus)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
(Canis familiaris)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
(Gallus gallus)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
(Mus musculus)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
(Rattus norvegicus)
K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
(Sus scrofa)
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