Reactome | TRPA1 tetramer transports Ca2+ from extracellular region to cytosol

TRPA1 tetramer transports Ca2+ from extracellular region to cytosol

Stable Identifier

R-HSA-9701055

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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TRPA1 tetramer transports Ca2+ from extracellular region to cytosol

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All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010). Transient receptor potential cation channel subfamily A member 1 (TRPA1) is a homotetrametric channel expressed in the PNS and CNS which involved in pain detection (Moparthy et al. 2014, Paulsen et al. 2015). It acts as a sensor of chemical, thermal, mechanical and somotic stimuli (Zhang et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
20025796	Structure-functional intimacies of transient receptor potential channels Zaelzer, C, Brauchi, S, Latorre, R	Q. Rev. Biophys.	2009
25855297	Structure of the TRPA1 ion channel suggests regulatory mechanisms Cheng, Y, Armache, JP, Gao, Y, Julius, D, Paulsen, CE	Nature	2015
25389312	Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain Survery, S, Kreir, M, Simonsen, C, Moparthi, L, Högestätt, ED, Kjellbom, P, Johanson, U, Zygmunt, PM	Proc. Natl. Acad. Sci. U.S.A.	2014
20716668	International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family Clapham, DE, Wu, LJ, Sweet, TB	Pharmacol. Rev.	2010