TRPV1 transports Ca2+ from extracellular region to cytosol

Stable Identifier
R-HSA-9701141
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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All functionally characterized TRP channels are permeable to the divalent cation Ca2+ except TRPM4 and 5 (Latorre et al. 2009, Wu et al. 2010). Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a ligand-activated non-selective calcium permeant cation channel involved in the detection of noxious chemical and thermal stimuli. It is involved in the mediation of inflammatory pain and hyperalgesia (Hayes et al. 2000, Cortright et al. 2001).

Literature References
PubMed ID Title Journal Year
11243859 The tissue distribution and functional characterization of human VR1

Cortright, DN, Crandall, M, Sanchez, JF, Zou, T, Krause, JE, White, G

Biochem. Biophys. Res. Commun. 2001
20025796 Structure-functional intimacies of transient receptor potential channels

Latorre, R, Zaelzer, C, Brauchi, S

Q. Rev. Biophys. 2009
11050376 Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

Hayes, P, Meadows, HJ, Gunthorpe, MJ, Harries, MH, Duckworth, DM, Cairns, W, Harrison, DC, Clarke, CE, Ellington, K, Prinjha, RK, Barton, AJ, Medhurst, AD, Smith, GD, Topp, S, Murdock, P, Sanger, GJ, Terrett, J, Jenkins, O, Benham, CD, Randall, AD, Gloger, IS, Davis, JB

Pain 2000
20716668 International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

Wu, LJ, Sweet, TB, Clapham, DE

Pharmacol. Rev. 2010
Participants
Participates
Catalyst Activity

voltage-gated calcium channel activity of TRPV1 [plasma membrane]

This event is regulated
Positively by
Regulator
Summation

Regulates 'TRPs transport extracellular Ca2+ to cytosol' DB_ID3295579

Orthologous Events
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