Reactome | p-Y705, p-S727 STAT3 dimer translocates to the nucleus

p-Y705, p-S727 STAT3 dimer translocates to the nucleus

Stable Identifier

R-HSA-9701529

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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p-Y705, p-S727 STAT3 dimer translocates to the nucleus

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After phosphorylation of Y705 (and in some cases, of S727 in an independent event), STAT3 dimerizes and translocates to the nucleus where it binds to its cognate TTCN(2-4)GGAA site in the promoter of target genes. STAT3-mediated gene expression contributes to cellular proliferation, differentiation and survival (reviewed in Yu et al, 2014; Guanizo et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
29873274	STAT3: a multifaceted oncoprotein Gough, DJ, Garama, DJ, Guanizo, AC, Fernando, CD	Growth Factors	2018
25342631	Revisiting STAT3 signalling in cancer: new and unexpected biological functions Jove, R, Buettner, R, Lee, H, Herrmann, A, Yu, H	Nat. Rev. Cancer	2014