Reactome | BRCA1 M1411T [nucleoplasm]

BRCA1 M1411T [nucleoplasm]

Stable Identifier

R-HSA-9702140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BRCA1 Met1411Thr

Icon

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of DNA repair (Homo sapiens)
  - Diseases of DNA Double-Strand Break Repair (Homo sapiens)
    - Defective HDR through Homologous Recombination (HRR) due to BRCA1 loss-of-function (Homo sapiens)
      - Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
        
        Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Homo sapiens)
        
        Defective BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        Defective p-5S-BRCA1:p-2T-BARD1 [nucleoplasm] (Homo sapiens)
        
        BRCA1 mutants (PALB2 binding) [nucleoplasm] (Homo sapiens)
        
        BRCA1 M1411T [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
19369211	PALB2 is an integral component of the BRCA complex required for homologous recombination repair Sy, SM, Huen, MS, Chen, J	Proc Natl Acad Sci U S A	2009

External Reference Information

External Reference

UniProt:P38398 BRCA1

Gene Names

BRCA1, RNF53

Chain

chain:1-1863

Reference Genes

BioGPS Gene:672 BRCA1

COSMIC (genes):BRCA1 BRCA1

CTD Gene:672 BRCA1

dbSNP Gene:672 BRCA1

ENSEMBL:ENSG00000012048 BRCA1

HGNC:1100 BRCA1

KEGG Gene (Homo sapiens):672 BRCA1

Monarch:672 BRCA1

NCBI Gene:672 BRCA1

OMIM:113705 BRCA1

UCSC:P38398 BRCA1

Reference Transcript

Other Identifiers

0000510746

11735584_x_at

11744317_x_at

11749632_a_at

11750373_a_at

11755416_x_at

16845349

1993_s_at

204531_s_at

211851_x_at

2395433

33724_at

3506844

3758316

3758318

3758319

3758321

3758323

3758324

3758334

3758335

3758337

3758341

3758342

3758344

3758345

3758350

3758351

3758355

3758357

3758358

3758359

3758360

3758361

3758362

3758363

3758364

3758366

3758367

3758368

3758371

3758372

3758374

3758375

604_at

672

69578_at

8015769

A_23_P207400

GE475511

GE59309

GO:0000151

GO:0000228

GO:0000278

GO:0000724

GO:0000729

GO:0000793

GO:0000794

GO:0000800

GO:0000976

GO:0003674

GO:0003677

GO:0003684

GO:0003713

GO:0003723

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005815

GO:0005856

GO:0005886

GO:0006259

GO:0006260

GO:0006281

GO:0006301

GO:0006302

GO:0006303

GO:0006310

GO:0006349

GO:0006357

GO:0006464

GO:0006629

GO:0006631

GO:0006633

GO:0006950

GO:0006974

GO:0007010

GO:0007049

GO:0007059

GO:0007098

GO:0007165

GO:0008092

GO:0008150

GO:0008219

GO:0008270

GO:0008274

GO:0008630

GO:0009048

GO:0009058

GO:0009790

GO:0010212

GO:0010575

GO:0010628

GO:0015631

GO:0016567

GO:0016579

GO:0016604

GO:0016740

GO:0019899

GO:0022607

GO:0031398

GO:0031436

GO:0031625

GO:0032991

GO:0033147

GO:0034641

GO:0035066

GO:0035067

GO:0043009

GO:0043167

GO:0043226

GO:0043627

GO:0044030

GO:0044281

GO:0044818

GO:0045717

GO:0045739

GO:0045766

GO:0045892

GO:0045893

GO:0045944

GO:0046600

GO:0046872

GO:0048646

GO:0048856

GO:0051276

GO:0051571

GO:0051572

GO:0051573

GO:0051574

GO:0051865

GO:0070063

GO:0070317

GO:0070512

GO:0070531

GO:0071158

GO:0071356

GO:0071681

GO:0072425

GO:0085020

GO:1901796

GO:1902042

GO:1990904

GO:2000378

GO:2000617

GO:2000620

HMNXSV003012854

ILMN_1738027

ILMN_2311089

L78833_cds1_at

PH_hs_0011459

TC17001553.hg

TC17002645.hg

U64805_s_at

g2218153_3p_a_at

g6552300_3p_a_at

Participates

as a member of

BRCA1 mutants (PALB2 binding) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

polySUMO2,3-BRCA1 [nucleoplasm]

monoSUMO1-K109-BRCA1 [nucleoplasm]

BRCA1 M1400V [nucleoplasm]

BRCA1 L1407P [nucleoplasm]

BRCA1 Y777* [nucleoplasm]

BRCA1 S1009* [nucleoplasm]

BRCA1 P724Lfs*12 [nucleoplasm]

BRCA1 S451* [nucleoplasm]

BRCA1 S864* [nucleoplasm]

BRCA1 P897Kfs*5 [nucleoplasm]

BRCA1 N555Kfs*17 [nucleoplasm]

BRCA1 Y1127Sfs*6 [nucleoplasm]

BRCA1 S886Cfs*16 [nucleoplasm]

BRCA1 V83Cfs*2 [nucleoplasm]

BRCA1 T464Pfs*11 [nucleoplasm]

BRCA1 G813Dfs*2 [nucleoplasm]

BRCA1 V340Gfs*6 [nucleoplasm]

BRCA1 Y655* [nucleoplasm]

BRCA1 W372* [nucleoplasm]

BRCA1 Y655Vfs*18 [nucleoplasm]

BRCA1 S242Rfs*5 [nucleoplasm]

BRCA1 E111Gfs*3 [nucleoplasm]

BRCA1 R71Kfs*10 [nucleoplasm]

BRCA1 A224Gfs*4 [nucleoplasm]

BRCA1 Q317* [nucleoplasm]

BRCA1 E1004* [nucleoplasm]

BRCA1 Q541* [nucleoplasm]

BRCA1 Q667* [nucleoplasm]

BRCA1 N909Kfs*6 [nucleoplasm]

BRCA1 T922Lfs*77 [nucleoplasm]

BRCA1 N567Pfs*16 [nucleoplasm]

BRCA1 N555Ifs*17 [nucleoplasm]

BRCA1 S988* [nucleoplasm]

BRCA1 S1007* [nucleoplasm]

BRCA1 E1288Kfs*19 [nucleoplasm]

BRCA1 V1176Ffs*34 [nucleoplasm]

BRCA1 S1217Rfs*21 [nucleoplasm]

BRCA1 E1282Afs*26 [nucleoplasm]

BRCA1 Q210Sfs*6 [nucleoplasm]

BRCA1 E453Rfs*22 [nucleoplasm]

BRCA1 E729Rfs*10 [nucleoplasm]

BRCA1 R1203* [nucleoplasm]

BRCA1 E686* [nucleoplasm]

BRCA1 R388* [nucleoplasm]

BRCA1 L290Yfs*8 [nucleoplasm]

BRCA1 E648* [nucleoplasm]

BRCA1 N1045* [nucleoplasm]

BRCA1 Q172Nfs*62 [nucleoplasm]

BRCA1 D1156Cfs*2 [nucleoplasm]

BRCA1 E597* [nucleoplasm]

BRCA1 Q210* [nucleoplasm]

BRCA1 E515* [nucleoplasm]

BRCA1 N287Qfs*6 [nucleoplasm]

BRCA1 Q169* [nucleoplasm]

BRCA1 N1121Kfs*12 [nucleoplasm]

BRCA1 E572* [nucleoplasm]

BRCA1 L1276* [nucleoplasm]

BRCA1 L431* [nucleoplasm]

BRCA1 E1214* [nucleoplasm]

BRCA1 L474* [nucleoplasm]

BRCA1 L502Afs*2 [nucleoplasm]

BRCA1 E1013Nfs*4 [nucleoplasm]

BRCA1 E1112Dfs*5 [nucleoplasm]

BRCA1 Q1144* [nucleoplasm]

BRCA1 Q94* [nucleoplasm]

BRCA1 N1265Kfs*4 [nucleoplasm]

BRCA1 C1146Lfs*8 [nucleoplasm]

BRCA1 Q934* [nucleoplasm]

BRCA1 D295Tfs*3 [nucleoplasm]

BRCA1 R1188Efs*3 [nucleoplasm]

BRCA1 C1225Sfs*10 [nucleoplasm]

BRCA1 R446Sfs*9 [nucleoplasm]

BRCA1 L668Pfs*33 [nucleoplasm]

BRCA1 A521Qfs*11 [nucleoplasm]

BRCA1 N1029Kfs*3 [nucleoplasm]

BRCA1 E1115* [nucleoplasm]

BRCA1 Q544* [nucleoplasm]

BRCA1 E577* [nucleoplasm]

BRCA1 P115* [nucleoplasm]

BRCA1 Q126* [nucleoplasm]

BRCA1 E457* [nucleoplasm]

BRCA1 A878Gfs*24 [nucleoplasm]

BRCA1 Q1281* [nucleoplasm]

BRCA1 Q202* [nucleoplasm]

BRCA1 N714Kfs*4 [nucleoplasm]

BRCA1 Q1240* [nucleoplasm]

BRCA1 K1183Rfs*4 [nucleoplasm]

BRCA1 K654Sfs*47 [nucleoplasm]

BRCA1 K1254Nfs*11 [nucleoplasm]

BRCA1 E1167* [nucleoplasm]

BRCA1 K1037* [nucleoplasm]

BRCA1 G911* [nucleoplasm]

BRCA1 G535* [nucleoplasm]

BRCA1 E111* [nucleoplasm]

BRCA1 E1107* [nucleoplasm]

BRCA1 E1033* [nucleoplasm]

BRCA1 E149* [nucleoplasm]

BRCA1 E1250* [nucleoplasm]

BRCA1 K467* [nucleoplasm]

BRCA1 E272* [nucleoplasm]

BRCA1 E1258* [nucleoplasm]

BRCA1 E1210* [nucleoplasm]

BRCA1 K1160* [nucleoplasm]

BRCA1 K519* [nucleoplasm]

BRCA1 E1112* [nucleoplasm]

BRCA1 E116* [nucleoplasm]

BRCA1 K935* [nucleoplasm]

BRCA1 K800* [nucleoplasm]

BRCA1 K894Tfs*8 [nucleoplasm]

BRCA1 K339Rfs*2 [nucleoplasm]

BRCA1 L1086Dfs*2 [nucleoplasm]

BRCA1 I986Sfs*14 [nucleoplasm]

BRCA1 K1079Nfs*2 [nucleoplasm]

BRCA1 K739Ifs*15 [nucleoplasm]

BRCA1 I925Nfs*13 [nucleoplasm]

BRCA1 K608Ifs*3 [nucleoplasm]

BRCA1 K893Rfs*107 [nucleoplasm]

BRCA1 H437* [nucleoplasm]

BRCA1 H816Qfs*3 [nucleoplasm]

BRCA1 F989Lfs*10 [nucleoplasm]

BRCA1 G928Afs*72 [nucleoplasm]

BRCA1 W372Yfs*5 [nucleoplasm]

BRCA1 E75Kfs*13 [nucleoplasm]

BRCA1 G948Efs*52 [nucleoplasm]

BRCA1 V757Ffs*8 [nucleoplasm]

BRCA1 H1284Tfs*23 [nucleoplasm]

BRCA1 E733* [nucleoplasm]

BRCA1 F869Vfs*35 [nucleoplasm]

BRCA1 E720* [nucleoplasm]

BRCA1 S426* [nucleoplasm]

BRCA1 E673* [nucleoplasm]

BRCA1 E787* [nucleoplasm]

BRCA1 E881* [nucleoplasm]

BRCA1 E848* [nucleoplasm]

BRCA1 E842* [nucleoplasm]

BRCA1 F989Lfs*11 [nucleoplasm]

BRCA1 G817Vfs*29 [nucleoplasm]

BRCA1 E836* [nucleoplasm]

BRCA1 G911Efs*89 [nucleoplasm]

BRCA1 E904* [nucleoplasm]

BRCA1 C64R [nucleoplasm]

BRCA1 C61G [nucleoplasm]

BRCA1 C39Y [nucleoplasm]

BRCA1 H41R [nucleoplasm]

BRCA1 C24R [nucleoplasm]

BRCA1 H41A [nucleoplasm]

BRCA1 M18T [nucleoplasm]

BRCA1 C47G [nucleoplasm]

BRCA1 C64G [nucleoplasm]

BRCA1 C44F [nucleoplasm]

BRCA1 T37R [nucleoplasm]

BRCA1 C27A [nucleoplasm]

BRCA1 H41Q [nucleoplasm]

BRCA1 Q12Tfs*5 [nucleoplasm]

BRCA1 E23Afs*18 [nucleoplasm]

BRCA1 C61Y [nucleoplasm]

BRCA1 C24F [nucleoplasm]

BRCA1 E23Rfs*18 [nucleoplasm]

BRCA1 E23Vfs*17 [nucleoplasm]

BRCA1 [nucleoplasm]

K6PolyUb-BRCA1 [nucleoplasm]

K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]

p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]

p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]

K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]

Modified Residues

Name

L-methionine 1411 replaced with L-threonine

Coordinate

1411

PsiMod

L-methionine removal [MOD:01643]

A protein modification that effectively removes or replaces an L-methionine.

L-threonine residue [MOD:00026]

A protein modification that effectively converts a source amino acid residue to L-threonine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
breast cancer	DOID:1612	malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor

Cross References

RefSeq

NP_009225.1, NP_009230.2, NP_009231.2, NP_009228.2, NP_009229.2

ClinGen

CA002723

OpenTargets

ENSG00000012048

ZINC - Substances

BRCA1_HUMAN

ZINC target

P38398

PRO

P38398

GlyGen

P38398

PDB

3K15, 1T29, 3K16, 4U4A, 1JM7, 1N5O, 4IGK, 3PXA, 1T15, 1T2U, 1JNX, 4IFI, 4Y2G, 3COJ, 3PXB, 2ING, 6G2I, 3K0H, 1T2V, 3PXC, 4Y18, 3K0K, 1Y98, 4OFB, 3PXD, 7LYB, 4JLU, 1OQA, 3PXE

IntEnz

2.3.2.27

HPA

ENSG00000012048-BRCA1

GeneCards

P38398

Ensembl

ENST00000461221, ENST00000461798, ENST00000491747, ENSP00000312236, ENST00000352993, ENST00000471181, ENSP00000418960, ENSP00000418548, ENSP00000350283, ENST00000468300, ENST00000357654, ENSG00000012048, ENSP00000418775, ENSP00000420705, ENSP00000417148, ENSP00000417988, ENST00000493795

Pharos - Targets

P38398

ZINC - Predictions - Purchasable

BRCA1_HUMAN

Orphanet

15377

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BX63 BRIP1	2	BRIP1 [cytosol] (R-HSA-2564781) p-S990,Ac-K1249-BRIP1 [nucleoplasm] (R-HSA-5687710)	0.976	28
UniProt:Q99728 BARD1	13	BARD1 G623E [nucleoplasm] (R-HSA-9699135) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 C83G [nucleoplasm] (R-HSA-9699139) K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 [nucleoplasm] (R-HSA-5659775)	0.951	17
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.909	27
UniProt:Q99708 RBBP8	4	Ac-K432,K526,K604-RBBP8 [nucleoplasm] (R-HSA-5685955) p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138) p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083) RBBP8 [nucleoplasm] (R-HSA-912399)	0.907	12
UniProt:Q6UWZ7 ABRAXAS1	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.818	15
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.811	16
UniProt:O15360 FANCA	1	FANCA [nucleoplasm] (R-HSA-419541)	0.747	5
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.727	8
UniProt:Q06609 RAD51	2	RAD51 [nucleoplasm] (R-HSA-62637) p-T309-RAD51 [nucleoplasm] (R-HSA-5685231)	0.718	6
UniProt:Q96RL1 UIMC1	1	UIMC1 [nucleoplasm] (R-HSA-5682574)	0.717	10
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.715	6
UniProt:P16104 H2AX	7	K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583)	0.714	4
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.7	5
UniProt:P27694 RPA1	2	polySUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644) RPA1 [nucleoplasm] (R-HSA-68461)	0.65	3
UniProt:Q14676 MDC1	6	monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061)	0.629	4
UniProt:P78347 GTF2I			0.61	5
UniProt:Q8WX92 NELFB	3	NELFB [nucleoplasm] (R-HSA-112427) NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526)	0.602	5
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.602	3
UniProt:Q6PJG6 BRAT1			0.602	6
UniProt:Q61188 Ezh2	1	Ezh2 [nucleoplasm] (R-MMU-5617899)	0.591	5
UniProt:P61956 SUMO2	5	SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) SUMO2 [nucleoplasm] (R-HSA-2984281) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546)	0.589	2
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481)	0.583	3
UniProt:Q9GZX5 ZNF350	1	ZNF350 [nucleoplasm] (R-HSA-1247526)	0.581	3
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.581	3
UniProt:Q16666 IFI16	1	IFI16 [cytosol] (R-HSA-1834934)	0.556	9
UniProt:P03126 VE6			0.544	7
UniProt:P03129 VE7			0.544	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.544	2
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.543	3
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.536	2
UniProt:Q13085 ACACA	2	Btn-ACACA [cytosol] (R-HSA-2976730) ACACA [cytosol] (R-HSA-1660609)	0.524	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.524	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	2
UniProt:Q6NZY4 ZCHC8			0.524	2
UniProt:P11388 TOP2A	3	monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367) TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298)	0.524	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.508	3
UniProt:Q7Z569 BRAP	2	ub-BRAP [cytosol] (R-HSA-5674001) BRAP [cytosol] (R-HSA-5672938)	0.508	3
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989)	0.508	2
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.499	4
UniProt:P40692 MLH1	3	MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 [nucleoplasm] (R-HSA-912495)	0.483	2
UniProt:P46736 BRCC3	2	BRCC3 [cytosol] (R-HSA-5691415) BRCC3 [nucleoplasm] (R-HSA-5682577)	0.483	2
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.483	4
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.463	3
UniProt:O14757 CHEK1	3	CHEK1 [cytosol] (R-HSA-205285) CHEK1 [nucleoplasm] (R-HSA-113826) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.463	3

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