Reactome | BRCA1 Q126* [nucleoplasm]

BRCA1 Q126* [nucleoplasm]

Stable Identifier

R-HSA-9702711

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BRCA1 Gln126*, BRCA1 Q126TER, BRCA1 Gln126TER

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Disease (Homo sapiens)

- Diseases of DNA repair (Homo sapiens)
  - Diseases of DNA Double-Strand Break Repair (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to BRCA1 loss of function (Homo sapiens)
      - Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding (Homo sapiens)
        
        Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:BCDX2 complex [nucleoplasm] (Homo sapiens)
        
        Defective 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2 [nucleoplasm] (Homo sapiens)
        
        Defective BRCA1-C complex [nucleoplasm] (Homo sapiens)
        
        Defective p-5S-BRCA1:p-2T-BARD1 [nucleoplasm] (Homo sapiens)
        
        BRCA1 mutants (PALB2 binding) [nucleoplasm] (Homo sapiens)
        
        BRCA1 Q126* [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P38398 BRCA1

Gene Names

BRCA1, RNF53

Chain

chain:1-1863

Reference Genes

BioGPS Gene:672 BRCA1

COSMIC (genes):BRCA1 BRCA1

CTD Gene:672 BRCA1

dbSNP Gene:672 BRCA1

ENSEMBL:ENSG00000012048 BRCA1

HGNC:1100 BRCA1

KEGG:hsa:672 BRCA1

Monarch:672 BRCA1

NCBI Gene:672 BRCA1

OMIM:113705 BRCA1

UCSC:P38398 BRCA1

Reference Transcript

Participates

as a candidate of

BRCA1 mutants (PALB2 binding) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

polySUMO2,3-BRCA1 [nucleoplasm]

monoSUMO1-K109-BRCA1 [nucleoplasm]

BRCA1 M1411T [nucleoplasm]

BRCA1 M1400V [nucleoplasm]

BRCA1 L1407P [nucleoplasm]

BRCA1 Y777* [nucleoplasm]

BRCA1 S1009* [nucleoplasm]

BRCA1 P724Lfs*12 [nucleoplasm]

BRCA1 S451* [nucleoplasm]

BRCA1 S864* [nucleoplasm]

BRCA1 P897Kfs*5 [nucleoplasm]

BRCA1 N555Kfs*17 [nucleoplasm]

BRCA1 Y1127Sfs*6 [nucleoplasm]

BRCA1 S886Cfs*16 [nucleoplasm]

BRCA1 V83Cfs*2 [nucleoplasm]

BRCA1 T464Pfs*11 [nucleoplasm]

BRCA1 G813Dfs*2 [nucleoplasm]

BRCA1 V340Gfs*6 [nucleoplasm]

BRCA1 Y655* [nucleoplasm]

BRCA1 W372* [nucleoplasm]

BRCA1 Y655Vfs*18 [nucleoplasm]

BRCA1 S242Rfs*5 [nucleoplasm]

BRCA1 E111Gfs*3 [nucleoplasm]

BRCA1 R71Kfs*10 [nucleoplasm]

BRCA1 A224Gfs*4 [nucleoplasm]

BRCA1 Q317* [nucleoplasm]

BRCA1 E1004* [nucleoplasm]

BRCA1 Q541* [nucleoplasm]

BRCA1 Q667* [nucleoplasm]

BRCA1 N909Kfs*6 [nucleoplasm]

BRCA1 T922Lfs*77 [nucleoplasm]

BRCA1 N567Pfs*16 [nucleoplasm]

BRCA1 N555Ifs*17 [nucleoplasm]

BRCA1 S988* [nucleoplasm]

BRCA1 S1007* [nucleoplasm]

BRCA1 E1288Kfs*19 [nucleoplasm]

BRCA1 V1176Ffs*34 [nucleoplasm]

BRCA1 S1217Rfs*21 [nucleoplasm]

BRCA1 E1282Afs*26 [nucleoplasm]

BRCA1 Q210Sfs*6 [nucleoplasm]

BRCA1 E453Rfs*22 [nucleoplasm]

BRCA1 E729Rfs*10 [nucleoplasm]

BRCA1 R1203* [nucleoplasm]

BRCA1 E686* [nucleoplasm]

BRCA1 R388* [nucleoplasm]

BRCA1 L290Yfs*8 [nucleoplasm]

BRCA1 E648* [nucleoplasm]

BRCA1 N1045* [nucleoplasm]

BRCA1 Q172Nfs*62 [nucleoplasm]

BRCA1 D1156Cfs*2 [nucleoplasm]

BRCA1 E597* [nucleoplasm]

BRCA1 Q210* [nucleoplasm]

BRCA1 E515* [nucleoplasm]

BRCA1 N287Qfs*6 [nucleoplasm]

BRCA1 Q169* [nucleoplasm]

BRCA1 N1121Kfs*12 [nucleoplasm]

BRCA1 E572* [nucleoplasm]

BRCA1 L1276* [nucleoplasm]

BRCA1 L431* [nucleoplasm]

BRCA1 E1214* [nucleoplasm]

BRCA1 L474* [nucleoplasm]

BRCA1 L502Afs*2 [nucleoplasm]

BRCA1 E1013Nfs*4 [nucleoplasm]

BRCA1 E1112Dfs*5 [nucleoplasm]

BRCA1 Q1144* [nucleoplasm]

BRCA1 Q94* [nucleoplasm]

BRCA1 N1265Kfs*4 [nucleoplasm]

BRCA1 C1146Lfs*8 [nucleoplasm]

BRCA1 Q934* [nucleoplasm]

BRCA1 D295Tfs*3 [nucleoplasm]

BRCA1 R1188Efs*3 [nucleoplasm]

BRCA1 C1225Sfs*10 [nucleoplasm]

BRCA1 R446Sfs*9 [nucleoplasm]

BRCA1 L668Pfs*33 [nucleoplasm]

BRCA1 A521Qfs*11 [nucleoplasm]

BRCA1 N1029Kfs*3 [nucleoplasm]

BRCA1 E1115* [nucleoplasm]

BRCA1 Q544* [nucleoplasm]

BRCA1 E577* [nucleoplasm]

BRCA1 P115* [nucleoplasm]

BRCA1 E457* [nucleoplasm]

BRCA1 A878Gfs*24 [nucleoplasm]

BRCA1 Q1281* [nucleoplasm]

BRCA1 Q202* [nucleoplasm]

BRCA1 N714Kfs*4 [nucleoplasm]

BRCA1 Q1240* [nucleoplasm]

BRCA1 K1183Rfs*4 [nucleoplasm]

BRCA1 K654Sfs*47 [nucleoplasm]

BRCA1 K1254Nfs*11 [nucleoplasm]

BRCA1 E1167* [nucleoplasm]

BRCA1 K1037* [nucleoplasm]

BRCA1 G911* [nucleoplasm]

BRCA1 G535* [nucleoplasm]

BRCA1 E111* [nucleoplasm]

BRCA1 E1107* [nucleoplasm]

BRCA1 E1033* [nucleoplasm]

BRCA1 E149* [nucleoplasm]

BRCA1 E1250* [nucleoplasm]

BRCA1 K467* [nucleoplasm]

BRCA1 E272* [nucleoplasm]

BRCA1 E1258* [nucleoplasm]

BRCA1 E1210* [nucleoplasm]

BRCA1 K1160* [nucleoplasm]

BRCA1 K519* [nucleoplasm]

BRCA1 E1112* [nucleoplasm]

BRCA1 E116* [nucleoplasm]

BRCA1 K935* [nucleoplasm]

BRCA1 K800* [nucleoplasm]

BRCA1 K894Tfs*8 [nucleoplasm]

BRCA1 K339Rfs*2 [nucleoplasm]

BRCA1 L1086Dfs*2 [nucleoplasm]

BRCA1 I986Sfs*14 [nucleoplasm]

BRCA1 K1079Nfs*2 [nucleoplasm]

BRCA1 K739Ifs*15 [nucleoplasm]

BRCA1 I925Nfs*13 [nucleoplasm]

BRCA1 K608Ifs*3 [nucleoplasm]

BRCA1 K893Rfs*107 [nucleoplasm]

BRCA1 H437* [nucleoplasm]

BRCA1 H816Qfs*3 [nucleoplasm]

BRCA1 F989Lfs*10 [nucleoplasm]

BRCA1 G928Afs*72 [nucleoplasm]

BRCA1 W372Yfs*5 [nucleoplasm]

BRCA1 E75Kfs*13 [nucleoplasm]

BRCA1 G948Efs*52 [nucleoplasm]

BRCA1 V757Ffs*8 [nucleoplasm]

BRCA1 H1284Tfs*23 [nucleoplasm]

BRCA1 E733* [nucleoplasm]

BRCA1 F869Vfs*35 [nucleoplasm]

BRCA1 E720* [nucleoplasm]

BRCA1 S426* [nucleoplasm]

BRCA1 E673* [nucleoplasm]

BRCA1 E787* [nucleoplasm]

BRCA1 E881* [nucleoplasm]

BRCA1 E848* [nucleoplasm]

BRCA1 E842* [nucleoplasm]

BRCA1 F989Lfs*11 [nucleoplasm]

BRCA1 G817Vfs*29 [nucleoplasm]

BRCA1 E836* [nucleoplasm]

BRCA1 G911Efs*89 [nucleoplasm]

BRCA1 E904* [nucleoplasm]

BRCA1 C64R [nucleoplasm]

BRCA1 C61G [nucleoplasm]

K6PolyUb,p-S988,S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]

p-S988,S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]

BRCA1 [nucleoplasm]

K6PolyUb-BRCA1 [nucleoplasm]

p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]

K6PolyUb,p-S1387,S1423,S1457,S1524-BRCA1 [nucleoplasm]

BRCA1 E23Vfs*17 [nucleoplasm]

BRCA1 E23Rfs*18 [nucleoplasm]

BRCA1 C24F [nucleoplasm]

BRCA1 C61Y [nucleoplasm]

BRCA1 E23Afs*18 [nucleoplasm]

BRCA1 Q12Tfs*5 [nucleoplasm]

BRCA1 H41Q [nucleoplasm]

BRCA1 C27A [nucleoplasm]

BRCA1 T37R [nucleoplasm]

BRCA1 C44F [nucleoplasm]

BRCA1 C64G [nucleoplasm]

BRCA1 C47G [nucleoplasm]

BRCA1 M18T [nucleoplasm]

BRCA1 H41A [nucleoplasm]

BRCA1 C24R [nucleoplasm]

BRCA1 H41R [nucleoplasm]

BRCA1 C39Y [nucleoplasm]

Modified Residues

Name

Nonsense mutation at L-glutamine 126

Coordinate

126

PsiMod

L-glutamine removal [MOD:01637]

A protein modification that effectively removes or replaces an L-glutamine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
skin melanoma	DOID:8923	malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma

Cross References

RefSeq

NP_009230.2, NP_009228.2, NP_009229.2, NP_009225.1, NP_009231.2

OpenTargets

ENSG00000012048

ENSEMBL

ENST00000491747, ENST00000471181, ENST00000352993, ENSP00000417148, ENSP00000418775, ENSP00000350283, ENSP00000498906, ENSP00000419103, ENSP00000417988, ENSG00000012048, ENST00000461798, ENST00000470026, ENSP00000478114, ENST00000357654, ENSP00000419274, ENSP00000420705, ENST00000493795, ENST00000494123, ENST00000618469, ENST00000461221, ENSP00000418548, ENSP00000418960, ENST00000468300, ENST00000652672, ENSP00000312236

ZINC - Substances

BRCA1_HUMAN

ZINC target

P38398

PRO

P38398

PDB

4Y18, 4IGK, 3K0H, 1T29, 3COJ, 2ING, 1JNX, 7LYB, 4Y2G, 1JM7, 1N5O, 4U4A, 1Y98, 3PXB, 3PXE, 7JZV, 3PXD, 3PXA, 6G2I, 1T2U, 3PXC, 1T2V, 1T15, 4JLU, 4OFB, 3K16, 3K15, 1OQA, 4IFI, 8GRQ, 3K0K

COSMIC

COSV104621631

GeneCards

BRCA1

HPA

ENSG00000012048-BRCA1

Pharos - Targets

P38398

Orphanet

BRCA1

ZINC - Predictions - Purchasable

BRCA1_HUMAN

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BX63 BRIP1	2	p-S990,Ac-K1249-BRIP1 [nucleoplasm] (R-HSA-5687710) BRIP1 [cytosol] (R-HSA-2564781)	0.979	33
UniProt:Q99728 BARD1	13	K6PolyUb,p-T714,T734-BARD1 [nucleoplasm] (R-HSA-9707286) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846) BARD1 [nucleoplasm] (R-HSA-5659775) K6PolyUb-BARD1 [nucleoplasm] (R-HSA-9701024) BARD1 C83G [nucleoplasm] (R-HSA-9699139) BARD1 C50G [nucleoplasm] (R-HSA-9699137) BARD1 L44R [nucleoplasm] (R-HSA-9699126) BARD1 H68Y [nucleoplasm] (R-HSA-9699151) BARD1 W34R [nucleoplasm] (R-HSA-9699166) BARD1 G623W [nucleoplasm] (R-HSA-9699148) BARD1 C53W [nucleoplasm] (R-HSA-9700807) BARD1 C71Y [nucleoplasm] (R-HSA-9700808) BARD1 G623E [nucleoplasm] (R-HSA-9699135)	0.958	20
UniProt:Q99708 RBBP8	4	p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138) Ac-K-RBBP8 [nucleoplasm] (R-HSA-5685955) RBBP8 [nucleoplasm] (R-HSA-912399) p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083)	0.935	15
UniProt:Q86YC2 PALB2	20	PALB2 Y28C [nucleoplasm] (R-HSA-9724169) PALB2 L35P [nucleoplasm] (R-HSA-9724168) PALB2 L24S [nucleoplasm] (R-HSA-9724172) PALB2 L21A [nucleoplasm] (R-HSA-9704339) PALB2 R37H [nucleoplasm] (R-HSA-9724178) PALB2 L21F [nucleoplasm] (R-HSA-9704347) PALB2 E12* [nucleoplasm] (R-HSA-9704349) PALB2 R37C [nucleoplasm] (R-HSA-9724188) PALB2 L35F [nucleoplasm] (R-HSA-9704338) PALB2 L947F [nucleoplasm] (R-HSA-9724554) PALB2 G1043D [nucleoplasm] (R-HSA-9724584) PALB2 T1030I [nucleoplasm] (R-HSA-9704424) PALB2 T841Qfs10 [nucleoplasm] (R-HSA-9704749) PALB2 L1119P [nucleoplasm] (R-HSA-9724589) PALB2 L947S [nucleoplasm] (R-HSA-9724557) PALB2 L1143P [nucleoplasm] (R-HSA-9704428) PALB2 L1070P [nucleoplasm] (R-HSA-9724556) PALB2 C77Vfs100 [nucleoplasm] (R-HSA-9704738) PALB2 L939W [nucleoplasm] (R-HSA-9704417) PALB2 L961P [nucleoplasm] (R-HSA-9724583)	0.909	27
UniProt:Q6UWZ7 FAM175A	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.86	16
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.811	16
UniProt:Q96RL1 UIMC1	1	UIMC1 [nucleoplasm] (R-HSA-5682574)	0.78	13
UniProt:O15360 FANCA	2	FANCA [cytosol] (R-HSA-420796) FANCA [nucleoplasm] (R-HSA-419541)	0.747	5
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.727	8
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.718	6
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.715	6
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.714	4
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.7	5
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.65	4
UniProt:P27694 RPA1	2	RPA1 [nucleoplasm] (R-HSA-68461) polySUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644)	0.65	3
UniProt:Q14676 MDC1	6	MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546)	0.629	4
UniProt:P40692 MLH1	3	MLH1 [nucleoplasm] (R-HSA-912495) MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526)	0.615	3
UniProt:P46736 BRCC3	2	BRCC3 [nucleoplasm] (R-HSA-5682577) BRCC3 [cytosol] (R-HSA-5691415)	0.615	3
UniProt:P78347 GTF2I			0.61	5
UniProt:Q8WX92 NELFB	3	NELFB [cytosol] (R-HSA-9603526) NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [nucleoplasm] (R-HSA-112427)	0.602	5
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.602	3
UniProt:Q6PJG6 BRAT1			0.602	6
UniProt:Q61188 Ezh2	1	Ezh2 [nucleoplasm] (R-MMU-5617899)	0.591	5
UniProt:P61956 SUMO2	6	lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2 [nucleoplasm] (R-HSA-2984281) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837)	0.589	2
UniProt:Q86YA3 ZGRF1			0.584	4
UniProt:Q9BXW9 FANCD2	3	FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481)	0.583	3
UniProt:Q9GZX5 ZNF350	1	ZNF350 [nucleoplasm] (R-HSA-1247526)	0.581	3
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.581	3
UniProt:Q16666 IFI16	1	IFI16 [cytosol] (R-HSA-1834934)	0.556	9
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.544	2
UniProt:P03126 VE6			0.544	7
UniProt:P03129 VE7			0.544	5
UniProt:Q92560 BAP1	1	BAP1 [nucleoplasm] (R-HSA-5689665)	0.543	3
UniProt:Q13085 ACACA	2	Btn-ACACA [cytosol] (R-HSA-2976730) ACACA [cytosol] (R-HSA-1660609)	0.524	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.524	2
UniProt:Q6NZY4 ZCCHC8	1	ZCCHC8 [nucleoplasm] (R-HSA-8985573)	0.524	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.524	3
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.508	2
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.508	3
UniProt:Q7Z569 BRAP	2	ub-BRAP [cytosol] (R-HSA-5674001) BRAP [cytosol] (R-HSA-5672938)	0.508	3
UniProt:O75330 HMMR	2	HMMR [plasma membrane] (R-HSA-2160885) HMMR [cytosol] (R-HSA-8861624)	0.499	4
UniProt:Q96SB3 NEB2			0.499	4
UniProt:Q9NWV8 BABAM1	2	BABAM1 [nucleoplasm] (R-HSA-5682582) BABAM1 [cytosol] (R-HSA-5691418)	0.483	2
UniProt:Q9ULW0 TPX2	2	TPX2 [nucleoplasm] (R-HSA-2564700) TPX2 [cytosol] (R-HSA-8853407)	0.483	4
UniProt:Q9NXR7 BRE	2	BRE [nucleoplasm] (R-HSA-5682579) BRE [cytosol] (R-HSA-5691413)	0.483	2
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [cytosol] (R-HSA-75813) p-T286-CCND1 [nucleoplasm] (R-HSA-75811)	0.463	3
UniProt:O14757 CHEK1	3	p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838) CHEK1 [nucleoplasm] (R-HSA-113826) CHEK1 [cytosol] (R-HSA-205285)	0.463	3

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