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SPTBN1(2-159)-FLT3(570-993) fusion [cytosol]
Stable Identifier
R-HSA-9703316
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Spectrin beta chain, non-erythrocytic 1, SPTB2_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 fusion proteins (Homo sapiens)
FLT3 fusion dimers autophosphorylate (Homo sapiens)
FLT3 fusion dimers [cytosol] (Homo sapiens)
SPTBN1(2-159)-FLT3570-993) fusion dimer [cytosol] (Homo sapiens)
SPTBN1(2-159)-FLT3(570-993) fusion [cytosol] (Homo sapiens)
Ligand-independent dimerization of FLT3 fusion proteins (Homo sapiens)
FLT3 fusion dimers [cytosol] (Homo sapiens)
SPTBN1(2-159)-FLT3570-993) fusion dimer [cytosol] (Homo sapiens)
SPTBN1(2-159)-FLT3(570-993) fusion [cytosol] (Homo sapiens)
FLT3 fusion proteins [cytosol] (Homo sapiens)
SPTBN1(2-159)-FLT3(570-993) fusion [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17764812
A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy
Grand, FH
,
Zhang, L
,
Russell, NH
,
Cross, NC
,
Chase, A
,
Iqbal, S
2007
External Reference Information
External Reference
UniProt:Q01082 SPTBN1
Gene Names
SPTBN1, SPTB2
Chain
initiator methionine:, chain:2-2364
Reference Genes
BioGPS Gene:6711 SPTBN1
COSMIC (genes):SPTBN1 SPTBN1
CTD Gene:6711 SPTBN1
dbSNP Gene:6711 SPTBN1
ENSEMBL:ENSG00000115306 SPTBN1
ENSEMBL_homo_sapiens_GENE:ENSG00000115306.16 SPTBN1
HGNC:11275 SPTBN1
KEGG Gene (Homo sapiens):6711 SPTBN1
Monarch:6711 SPTBN1
NCBI Gene:6711 SPTBN1
OMIM:182790 SPTBN1
UCSC:Q01082 SPTBN1
Reference Transcript
RefSeq:XM_017004781.1 SPTBN1
RefSeq:XM_006712087.2 SPTBN1
RefSeq:XM_017004779.1 SPTBN1
RefSeq:NM_003128.2 SPTBN1
RefSeq:XM_017004780.1 SPTBN1
RefSeq:XM_005264517.2 SPTBN1
RefSeq:NM_178313.2 SPTBN1
Other Identifiers
11716418_a_at
11716419_at
11716420_s_at
11716421_at
11716422_x_at
11716423_a_at
11722689_a_at
11722690_at
11758629_s_at
16880122
200671_PM_s_at
200671_s_at
200672_PM_x_at
200672_x_at
212071_PM_s_at
212071_s_at
215918_PM_s_at
215918_s_at
226342_PM_at
226342_at
230540_PM_at
230540_at
242220_PM_at
242220_at
2482506
2482507
2482511
2482512
2482527
2482528
2482529
2482530
2482542
2482547
2482549
2482550
2482551
2482554
2482555
2482556
2482557
2482558
2482559
2482560
2482563
2482564
2482566
2482568
2482573
2482577
2482578
2482581
2482582
2482584
2482585
2482586
2482587
2482588
2482589
2482590
2482592
2482593
2482594
2482597
2482598
2482600
2482601
2482602
2482603
2482604
2482605
2482606
2482607
2482608
2482609
2482610
2482611
2482612
2482613
2482614
2482615
2482616
2482618
2482620
2482621
2482622
2482623
2482624
2482625
39452_s_at
39556_at
45202_at
52616_at
53241_at
58823_s_at
6711
73102_at
74748_s_at
8041995
81959_at
90584_at
A_14_P121454
A_33_P3258467
A_33_P3258472
GE55162
GE58172
GE84893
GE877747
GO:0000278
GO:0000281
GO:0000910
GO:0003723
GO:0003779
GO:0005198
GO:0005200
GO:0005515
GO:0005516
GO:0005543
GO:0005576
GO:0005615
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0007009
GO:0007010
GO:0007182
GO:0007417
GO:0008091
GO:0008092
GO:0008289
GO:0014069
GO:0014731
GO:0016020
GO:0016192
GO:0021556
GO:0023052
GO:0030036
GO:0030054
GO:0030506
GO:0030673
GO:0030863
GO:0030864
GO:0031430
GO:0032437
GO:0032743
GO:0032991
GO:0036211
GO:0042995
GO:0043001
GO:0043226
GO:0044877
GO:0045296
GO:0048856
GO:0051015
GO:0051020
GO:0051693
GO:0060390
GO:0061024
GO:0065003
GO:0070062
GO:0071709
GO:0071944
GO:0072659
GO:0098794
GO:0098978
GO:1903076
GO:1903078
HMNXSV003023445
Hs.107164.0.S1_3p_a_at
Hs.107164.4.S1_3p_a_at
Hs.107164.4.S1_3p_at
Hs.155033.0.A1_3p_at
Hs.236443.0.S1_3p_at
Hs.27286.0.A1_3p_at
Hs.324648.0.S1_3p_at
ILMN_1661335
ILMN_1690708
ILMN_1714228
M96803_at
PH_hs_0023033
TC02000315.hg
TC02003238.hg
TC02003240.hg
g4507194_3p_s_at
Participates
as a member of
FLT3 fusion proteins [cytosol] (Homo sapiens)
as a component of
SPTBN1(2-159)-FLT3570-993) fusion dimer [cytosol] (Homo sapiens)
Other forms of this molecule
SPTBN1(2-159)-p-6Y-FLT3(570-993) fusion [cytosol]
SPTBN1 [cytosol]
Modified Residues
Name
Insertion of residues 570 to 993 at 160 from UniProt:P36888 FLT3
Coordinate
160
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
chronic myeloid leukemia
DOID:8552
CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
RefSeq
XP_016860268.1
,
XP_016860270.1
,
NP_003119.2
,
XP_006712150.1
,
XP_005264574.1
,
XP_016860269.1
,
NP_842565.2
OpenTargets
ENSG00000115306
GeneCards
Q01082
HPA
ENSG00000115306-SPTBN1
Ensembl
ENSP00000349259
,
ENSG00000115306
,
ENSP00000334156
,
ENST00000356805
,
ENST00000333896
PRO
Q01082
Pharos - Targets
Q01082
PDB
3EDV
,
1AA2
,
1BKR
HMDB Protein
HMDBP08005
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13813 SPTAN1
6
SPTAN1 [cytosol]
(R-HSA-201601)
SPTAN1(1-1185) [cytosol]
(R-HSA-202944)
SPTAN1(1186-2472) [cytosol]
(R-HSA-202964)
SPTAN1 [tertiary granule lumen]
(R-HSA-6800874)
SPTAN1 [extracellular region]
(R-HSA-6806322)
SPTAN1 [specific granule lumen]
(R-HSA-6799533)
0.609
8
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.547
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
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