ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol]

Stable Identifier
R-HSA-9703318
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Transcription factor ETV6, ETV6_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
16761019 FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation

Sato, Y, Vu, HA, Motoji, T, Sakaki, Y, Xinh, PT, Tokunaga, K, Toyoda, A, Masuda, M

2006
External Reference Information
External Reference
Gene Names
ETV6, TEL, TEL1
Chain
chain:1-452
Reference Transcript
Other Identifiers
11743165_at
11743166_at
11743167_at
1638_at
16748407
205585_PM_at
205585_at
2120
225764_PM_at
225764_at
235056_PM_at
235056_at
3405041
3405042
3405082
3405100
3405101
3405102
3405103
3405120
3405121
3405122
3405132
3405134
3405135
3405136
3405142
3405152
3405156
3405157
3405162
3405163
3405164
3405175
3405177
38491_at
55594_at
58239_at
70395_at
7953981
92032_at
A_14_P113857
A_23_P105264
A_24_P372862
A_33_P3210343
A_33_P3356325
GE79814
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005730
GO:0005829
GO:0005886
GO:0006355
GO:0006357
GO:0007296
GO:0012501
GO:0016020
GO:0019904
GO:0022008
GO:0030154
GO:0043226
GO:0043565
GO:0045944
GO:0071425
GO:0097152
GO:0140110
GO:1990837
HMNXSV003053967
Hs.146381.2.S1_3p_at
Hs.293972.0.S1_3p_at
ILMN_1789596
PH_hs_0034188
TC12003210.hg
U11732_at
U63312_at
g4503610_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
O4'-phospho-L-tyrosine at 589
Coordinate
589
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 591
Coordinate
591
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 599
Coordinate
599
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 955
Coordinate
955
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 969
Coordinate
969
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
Insertion of residues 574 to 993 at 302 from UniProt:P36888 FLT3
Coordinate
302
Disease
Name Identifier Synonyms
myeloproliferative neoplasm DOID:2226 CMPD, chronic myeloproliferative disease, CMPD, U
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
GlyGen
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (5)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q13114 TRAF3  4 0.671 5
 UniProt:Q13526 PIN1  2 0.666 4
 UniProt:O75581 LRP6  8 0.643 3
 UniProt:Q16236 NFE2L2  13 0.625 5
 UniProt:O75197 LRP5  5 0.527 3
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