SARS-CoV-2-host interactions

Stable Identifier
R-HSA-9705683
DOI
10.3180/R-HSA-9705683.1
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
ReviewStatus
5/5
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SARS-CoV-2-host interactions
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Coronaviruses are a group of enveloped viruses with single‑stranded, positive‑sense RNA genomes. Each of the steps of viral replication - attachment and entry, translation of viral replicase, genome transcription and replication, translation of structural proteins, and virion assembly and release - involves host factors. These interactions can cause alterations in cellular structure and physiology, and activate host stress responses, autophagy, cell death, and processes of innate immunity (Fung TS & Liu DX 2019). This Reactome module describes molecular mechanisms by which severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) modulates innate and adaptive immune responses, autophagy, host translation, intracellular signaling and regulatory pathways, and PDZ-mediated cell-cell junctions, mostly annotated from studies of cells infected with SARS-CoV-2.
Literature References
PubMed ID Title Journal Year
33080218 SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Thai, J, Bruce, EA, Honson, DD, Ollikainen, N, Botten, JW, Miller, ZD, Voorhees, RM, Goldfarb, D, Guttman, M, Schmidt, MM, Chow, A, Blanco, MR, Quinodoz, SA, Majumdar, D, Bhat, P, Lin, AE, Stewart, DG, Banerjee, AK, Loney, C, Rihn, SJ, De Lorenzo, G, Chen, LM

Cell 2020
34281462 Manipulation of autophagy by SARS-CoV-2 proteins

Kirchhoff, F, Hirschenberger, M, Hayn, M, Koepke, L, Sparrer, KM

Autophagy 2021
31226023 Human Coronavirus: Host-Pathogen Interaction

Fung, TS, Liu, DX

Annu. Rev. Microbiol. 2019
34562466 Mechanisms of Antiviral Immune Evasion of SARS-CoV-2

Forero, A, Beyer, DK

J Mol Biol 2021
34022154 Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19

Lowery, SA, Perlman, S, Sariol, A

Cell Host Microbe 2021
33451855 Dysregulation of Cell Signaling by SARS-CoV-2

Agelidis, A, Koganti, R, Suryawanshi, RK, Shukla, D, Patil, CD

Trends Microbiol 2021
34471255 Cellular host factors for SARS-CoV-2 infection

Jansen, S, Daelemans, D, Vanstreels, E, Baggen, J

Nat Microbiol 2021
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Shamovsky, V  (2021-10-27)
Stephan, R  (2021-05-03)
Reviewed
Gillespie, ME  (2022-03-01)
Messina, F  (2022-02-18)
Created
Shamovsky, V  (2020-10-28)
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