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Active FLT3 binds to LCK
Stable Identifier
R-HSA-9706312
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
FLT3 signaling through SRC family kinases (Homo sapiens)
Active FLT3 binds to LCK (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SRC family of non-receptor tyrosine kinase LCK binds to tyrosine-phosphorylated FLT3. LCK-binding stimulates STAT signaling downstream of FLT3-ITD mutants and promotes cellular proliferation and tumor formation in mouse models (Marhall et al, 2017).
Literature References
PubMed ID
Title
Journal
Year
29062038
The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation
Kazi, JU
,
Rönnstrand, L
,
Marhäll, A
Sci Rep
2017
Participants
Input
Active FLT3 [plasma membrane]
(Homo sapiens)
LCK [cytosol]
(Homo sapiens)
Output
active FLT3:LCK [plasma membrane]
(Homo sapiens)
Participates
as an event of
FLT3 signaling through SRC family kinases (Homo sapiens)
Orthologous Events
Active FLT3 binds to LCK (Bos taurus)
Active FLT3 binds to LCK (Canis familiaris)
Active FLT3 binds to LCK (Mus musculus)
Active FLT3 binds to LCK (Sus scrofa)
Authored
Rothfels, K (2020-11-06)
Reviewed
Kazi, JU (2020-11-06)
Created
Rothfels, K (2020-11-04)
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