CBL Y371H [cytosol]

Stable Identifier
R-HSA-9706680
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
CBL E3 ubiquitin protein ligase , Signal transduction protein CBL, Proto-oncogene c-CBL, Casitas B-lineage lymphoma proto-oncogene
CBL Y371H [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
20622007 Novel oncogenic mutations of CBL in human acute myeloid leukemia that activate growth and survival pathways depend on increased metabolism

Griffin, JD, Croteau, NJ, Weisbach, H, Carroll, M, Podar, K, Fernandes, MS, Reddy, MM, Larson, RA, Band, H, Salgia, R, Reiter, A, Walz, C, Sattler, M

J Biol Chem 2010
External Reference Information
External Reference
Gene Names
CBL, CBL2, RNF55
Chain
chain:1-906
Reference Transcript
Other Identifiers
11724807_at
11724808_at
11724809_at
11724810_at
1568191_PM_at
1568191_at
16732296
206607_PM_at
206607_at
225231_PM_at
225231_at
225234_PM_at
225234_at
229010_PM_at
229010_at
243475_PM_at
243475_at
3352072
3352073
3352074
3352075
3352079
3352087
3352088
3352089
3352091
3352092
3352093
3352094
3352095
3352097
3352098
3352102
3352104
3352105
3352106
3352108
3352109
3352110
3352111
3352112
3352113
3352114
3352115
3352116
3352117
3352118
3352129
34416_at
47569_at
51017_at
55605_at
68600_at
7944493
867
A_14_P115221
A_14_P135012
A_14_P135711
A_14_P200324
A_23_P339191
A_23_P53226
A_33_P3256033
GE59823
GE87401
GE88439
GO:0000209
GO:0001784
GO:0002376
GO:0003824
GO:0004842
GO:0005509
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0005925
GO:0005929
GO:0006511
GO:0006513
GO:0006974
GO:0007165
GO:0007166
GO:0007173
GO:0007175
GO:0008584
GO:0010332
GO:0012501
GO:0014068
GO:0014823
GO:0016020
GO:0016192
GO:0016567
GO:0016600
GO:0016740
GO:0017124
GO:0019221
GO:0019901
GO:0022414
GO:0023051
GO:0023052
GO:0030163
GO:0030424
GO:0030426
GO:0030971
GO:0032487
GO:0033574
GO:0035635
GO:0036120
GO:0036211
GO:0036312
GO:0042059
GO:0042594
GO:0042995
GO:0043066
GO:0043226
GO:0043303
GO:0045121
GO:0045296
GO:0045471
GO:0045742
GO:0046872
GO:0046875
GO:0048260
GO:0048471
GO:0048856
GO:0051865
GO:0061630
GO:0090650
GO:0140096
GO:1990090
GO:1990782
GO:2000583
HMNXSV003013983
Hs.196521.0.A1_3p_at
Hs.41324.0.A1_3p_at
Hs.90960.0.A1_3p_at
Hs.90960.0.A2_3p_at
Hs2.423675.1.A1_3p_at
ILMN_1716080
ILMN_2181968
PH_hs_0022112
PH_hs_0031180
TC11001089.hg
TC11002905.hg
X57110_s_at
g4885116_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
L-tyrosine 371 replaced with L-histidine
Coordinate
371
PsiMod
A protein modification that effectively removes or replaces an L-tyrosine.
A protein modification that effectively converts a source amino acid residue to an L-histidine.
Disease
Name Identifier Synonyms
juvenile myelomonocytic leukemia DOID:0050458
acute myeloid leukemia DOID:9119 Leukemia, Myelocytic, acute, acute myeloblastic leukemia, acute myelogenous leukemia, AML - acute Myeloid Leukemia
chronic myeloid leukemia DOID:8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Cross References
RefSeq
COSMIC
OpenTargets
GeneCards
PRO
Pharos - Targets
Orphanet
HMDB Protein
Interactors (55)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q96B97 SH3KBP1  3 0.973 27
 UniProt:P00533 EGFR  20 0.964 26
 UniProt:P62993 GRB2  1 0.961 18
 UniProt:P27986 PIK3R1  16 0.94 16
 UniProt:P46108 CRK  1 0.91 12
 UniProt:P08581 MET  7 0.863 17
 UniProt:O43597 SPRY2  8 0.856 17
 UniProt:P12931 SRC  6 0.845 8
 UniProt:P46109 CRKL  2 0.826 8
 UniProt:P27348 YWHAQ  1 0.812 7
 UniProt:P06241 FYN  6 0.798 6
 UniProt:Q9Y5K6 CD2AP  1 0.796 7
 UniProt:P62994 Grb2  3 0.78 5
 UniProt:P29353 SHC1  5 0.77 5
 UniProt:P06239 LCK  4 0.75 4
 UniProt:P43405 SYK  6 0.743 7
 UniProt:Q15811 ITSN1  1 0.729 12
 UniProt:Q04917 YWHAH  1 0.725 4
 UniProt:P31946 YWHAB  1 0.725 4
 UniProt:P62258 YWHAE  1 0.708 5
 UniProt:P07949 RET  2 0.697 8
 UniProt:O14492 SH2B2  2 0.656 7
 UniProt:P61981 YWHAG  1 0.643 3
 UniProt:P63104 YWHAZ  2 0.643 3
 UniProt:O00459 PIK3R2  2 0.621 4
 UniProt:Q9C004 SPY4      0.611 9
 UniProt:P43403 ZAP70  3 0.611 3
 UniProt:P62837 UBE2D2  4 0.611 4
 UniProt:P16333 NCK1  2 0.611 3
 UniProt:P39688 Fyn  6 0.591 3
 UniProt:Q14155 ARHGEF7  1 0.591 9
 UniProt:Q92569 PIK3R3  2 0.57 4
 UniProt:P07948 LYN  7 0.564 2
 UniProt:P31947 SFN  1 0.564 2
 UniProt:P55085 F2RL1  1 0.556 3
 UniProt:P54253 ATX1      0.556 3
 IntAct:EBI-25865403 EHD27213144      0.556 3
 UniProt:P42858 HTT  1 0.556 18
 UniProt:Q13196 Q13196      0.544 2
 UniProt:Q8IZP0-2 ABI1      0.524 3
 UniProt:P08631-2 HCK      0.524 2
 UniProt:F1SDV6  5 0.524 2
 UniProt:Q96JA1 LRIG1  2 0.524 2
 UniProt:P06240 Lck  5 0.524 2
 UniProt:P08487 PLCG1      0.518 3
 UniProt:A0A0H3L6J6 A0A0H3L6J6      0.499 3
 UniProt:Q99962 SH3GL2  4 0.499 2
 UniProt:Q12929 EPS8  1 0.488 2
 UniProt:P42229 STAT5A  4 0.488 2
 UniProt:P40763 STAT3  12 0.488 2
 UniProt:P27986-2 PIK3R1      0.488 2
 UniProt:P46108-2 CRK      0.488 2
 UniProt:Q9UKG1 APPL1  1 0.488 2
 UniProt:A9UF07 A9UF07      0.462 4
 UniProt:P26450 Pik3r1  5 0.462 2
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