Reactome | UBXN1 [nucleoplasm]

UBXN1 [nucleoplasm]

Stable Identifier

R-HSA-9707052

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

UBX domain-containing protein 1, UBXN1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y263 PLAP

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External Reference Information

External Reference

UniProt:Q04323 UBXN1

Gene Names

UBXN1, SAKS1

Chain

initiator methionine:, chain:2-297

Reference Genes

BioGPS Gene:51035 UBXN1

COSMIC (genes):UBXN1 UBXN1

CTD Gene:51035 UBXN1

dbSNP Gene:51035 UBXN1

ENSEMBL:ENSG00000162191 UBXN1

HGNC:18402 UBXN1

KEGG:hsa:51035 UBXN1

Monarch:51035 UBXN1

NCBI Gene:51035 UBXN1

OMIM:616378 UBXN1

UCSC:Q04323 UBXN1

Reference Transcript

Participates

as a component of

UBXN1:K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] (Homo sapiens)

as an input of

UBXN1 binds BRCA1:BARD1 heterodimer (Homo sapiens)

Other forms of this molecule

UBXN1 [cytosol]

Inferred To

UBXN1 [nucleoplasm] (Bos taurus)

UBXN1 [nucleoplasm] (Canis familiaris)

UBXN1 [nucleoplasm] (Sus scrofa)

Ubxn1 [nucleoplasm] (Mus musculus)

Ubxn1 [nucleoplasm] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000301935, ENSP00000294119, ENST00000294119, ENSG00000162191, ENSP00000303991

OpenTargets

ENSG00000162191

GeneCards

UBXN1

HPA

ENSG00000162191-UBXN1

PRO

Q04323

Pharos - Targets

Q04323

GlyGen

Q04323

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y263 PLAP			0.666	5
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.666	7
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9UMX0-2 UBQLN1			0.556	3
UniProt:P40325 HUA1			0.556	3
UniProt:Q8WU02 Q8WU02			0.556	3
UniProt:Q9HCM9 TRIM39	1	TRIM39 [cytosol] (R-HSA-5688971)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q13617 CUL2	3	CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126) G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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