Reactome | LY96 [extracellular region]

LY96 [extracellular region]

Stable Identifier

R-HSA-9707658

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MD2

Locations in the PathwayBrowser for interactor UniProt:O00206 TLR4

Expand all

Literature References

PubMed ID	Title	Journal	Year
11593030	Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4 Segal, DM, Mazzoni, A, Spitzer, JA, Visintin, A	Proc Natl Acad Sci U S A	2001

External Reference Information

External Reference

UniProt:Q9Y6Y9 LY96

Gene Names

LY96, ESOP1, MD2

Chain

signal peptide:1-18, chain:19-160

Reference Genes

BioGPS Gene:23643 LY96

COSMIC (genes):LY96 LY96

CTD Gene:23643 LY96

dbSNP Gene:23643 LY96

ENSEMBL:ENSG00000154589 LY96

ENSEMBL_homo_sapiens_GENE:ENSG00000154589.7 LY96

HGNC:17156 LY96

KEGG Gene (Homo sapiens):23643 LY96

Monarch:23643 LY96

NCBI Gene:23643 LY96

OMIM:605243 LY96

UCSC:Q9Y6Y9 LY96

Reference Transcript

Other Identifiers

11728507_at

17070061

206584_PM_at

206584_at

23643

3103525

3103526

3103530

3103531

3103532

3103534

3103536

33956_at

8146934

A_23_P94230

GE53507

GO:0001530

GO:0001875

GO:0002224

GO:0002376

GO:0005515

GO:0005576

GO:0005768

GO:0005886

GO:0006954

GO:0006968

GO:0007166

GO:0008289

GO:0010008

GO:0015026

GO:0023052

GO:0031410

GO:0031663

GO:0031666

GO:0032496

GO:0032497

GO:0032760

GO:0034142

GO:0035662

GO:0043226

GO:0043235

GO:0045087

GO:0046696

GO:0060089

GO:0071222

GO:0098542

HMNXSV003041703

ILMN_1724533

PH_hs_0004099

TC08000487.hg

g7662503_3p_at

Participates

as a component of

Hemes:LY96 [extracellular region] (Homo sapiens)

as an input of

Hemes bind LY96 (Homo sapiens)

Other forms of this molecule

LY96 [endosome membrane]

2xN4GlycoAsn-LY96 [plasma membrane]

Inferred To

LY96 [extracellular region] (Bos taurus)

LY96 [extracellular region] (Canis familiaris)

LY96 [extracellular region] (Gallus gallus)

LY96 [extracellular region] (Sus scrofa)

Ly96 [extracellular region] (Mus musculus)

Ly96 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001182726.1, NP_056179.3

Guide to Pharmacology - Targets

2890

OpenTargets

ENSG00000154589

GeneCards

Q9Y6Y9

HPA

ENSG00000154589-LY96

Ensembl

ENSP00000284818, ENST00000284818, ENSG00000154589, ENST00000518893, ENSP00000430533

PRO

Q9Y6Y9

Pharos - Targets

Q9Y6Y9

HMDB Protein

HMDBP13763

PDB

3FXI, 2E56, 2Z65, 4G8A, 3ULA, 2E59

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00206-1 TLR4			0.822	5
UniProt:O00206 TLR4	2	TLR4 [endosome membrane] (R-HSA-2201285) 2xN4GlycoAsn-TLR4 [plasma membrane] (R-HSA-166045)	0.743	7
UniProt:Q14696 MESD			0.556	3
UniProt:P80188 LCN2	2	LCN2 [specific granule lumen] (R-HSA-6799614) LCN2 [extracellular region] (R-HSA-5215934)	0.556	3

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