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BACH1 [nucleoplasm]
Stable Identifier
R-HSA-9707688
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
Regulation of HMOX1 expression and activity (Homo sapiens)
HMOX1 gene produces HMOX1 dimer (Homo sapiens)
BACH1:MAFK [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
NFE2L2-dependent HMOX1 gene expression (Homo sapiens)
BACH1:MAFK [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
Regulation of BACH1 activity (Homo sapiens)
BACH1 binds MAFK (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
BACH1:MAFK [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
BACH1 is phosphorylated at tyrosine 483 (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
BACH1 translocates from the cytosol to the nucleoplasm (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)
BACH1:FBXL17 [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
BACH1:FBXL17 [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
FBXL17 binds BACH1:MAFK (Homo sapiens)
BACH1:FBXL17 [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
BACH1:MAFK [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
BACH1:FBXL17 [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
Heme signaling (Homo sapiens)
BACH1 binds MAFK (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
BACH1:MAFK [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
HMOX1 gene produces HMOX1 dimer (Homo sapiens)
BACH1:MAFK [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
Hemes bind to BACH1:MAFK (Homo sapiens)
BACH1:Hemes [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
BACH1:MAFK [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
XPO1 (CRM1) binds to BACH1:Hemes (Homo sapiens)
BACH1:Hemes [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
XPO1:BACH1:Hemes [nucleoplasm] (Homo sapiens)
BACH1:Hemes [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
XPO1:BACH1:Hemes are transported out of the nucleus (Homo sapiens)
XPO1:BACH1:Hemes [nucleoplasm] (Homo sapiens)
BACH1:Hemes [nucleoplasm] (Homo sapiens)
BACH1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14867 BACH1
Gene Names
BACH1
Chain
chain:1-736
Reference Genes
BioGPS Gene:571 BACH1
COSMIC (genes):BACH1 BACH1
CTD Gene:571 BACH1
dbSNP Gene:571 BACH1
ENSEMBL:ENSG00000156273 BACH1
ENSEMBL_homo_sapiens_GENE:ENSG00000156273.16 BACH1
HGNC:935 BACH1
KEGG Gene (Homo sapiens):571 BACH1
Monarch:571 BACH1
NCBI Gene:571 BACH1
OMIM:602751 BACH1
UCSC:O14867 BACH1
Reference Transcript
RefSeq:NM_206866.2 BACH1
RefSeq:NM_001186.3 BACH1
Other Identifiers
100379661
11726369_at
11726370_a_at
204194_PM_at
204194_at
210818_PM_s_at
210818_s_at
31895_at
3917310
3917311
3917312
3917315
3917316
3917317
3917318
3917319
3917320
3917324
3917325
3917326
3917327
3917334
571
8068105
A_23_P211047
GE53107
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006281
GO:0006351
GO:0006355
GO:0006357
GO:0019222
GO:0020037
GO:0043226
GO:0045944
GO:0090575
GO:0098531
GO:0140110
HMNXSV003046100
HMNXSV003048890
ILMN_1681583
ILMN_1807181
PH_hs_0009287
g2565399_3p_a_at
g4502352_3p_at
Participates
as an input of
BACH1 is phosphorylated at tyrosine 483 (Homo sapiens)
BACH1 binds MAFK (Homo sapiens)
as a component of
BACH1:Hemes [nucleoplasm] (Homo sapiens)
BACH1:FBXL17 [nucleoplasm] (Homo sapiens)
BACH1:MAFK [nucleoplasm] (Homo sapiens)
as an output of
BACH1 translocates from the cytosol to the nucleoplasm (Homo sapiens)
Other forms of this molecule
BACH1 [cytosol]
PolyUb-BACH1 [nucleoplasm]
p-Y483 BACH1 [nucleoplasm]
p-Y483 BACH1 [cytosol]
Inferred To
Dmel\CG15725 [nucleoplasm]
(Drosophila melanogaster)
BACH1 [nucleoplasm]
(Bos taurus)
BACH1 [nucleoplasm]
(Canis familiaris)
BACH1 [nucleoplasm]
(Gallus gallus)
BACH1 [nucleoplasm]
(Sus scrofa)
bach1 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of BACH1 [nucleoplasm]
(Caenorhabditis elegans)
Bach1 [nucleoplasm]
(Mus musculus)
Bach1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_996749.1
,
NP_001177.1
OpenTargets
ENSG00000156273
GeneCards
O14867
HPA
ENSG00000156273-BACH1
Ensembl
ENST00000399921
,
ENST00000286800
,
ENSP00000382805
,
ENSG00000156273
,
ENSP00000286800
PRO
O14867
Pharos - Targets
O14867
PDB
2IHC
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15525 MAFG
1
MAFG [nucleoplasm]
(R-HSA-1008212)
0.829
8
UniProt:Q9ULX9 MAFF
1
MAFF [nucleoplasm]
(R-HSA-1008261)
0.759
6
UniProt:Q9Y5Q3 MAFB
1
MAFB [nucleoplasm]
(R-HSA-3788667)
0.75
5
UniProt:P15336 ATF2
2
ATF2 [nucleoplasm]
(R-HSA-450336)
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
0.713
3
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.659
3
UniProt:O60675 MAFK
1
MAFK [nucleoplasm]
(R-HSA-1008242)
0.643
4
UniProt:Q9UF56 FBXL17
1
FBXL17 [nucleoplasm]
(R-HSA-9708570)
0.643
5
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.623
2
UniProt:P17544 ATF7
0.59
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:P40337-2 VHL
0.556
3
UniProt:Q8N427 TXND3
0.534
2
UniProt:Q9H4H8-2 FAM83D
0.527
2
UniProt:Q9BQ83 SLX1A
1
SLX1A [nucleoplasm]
(R-HSA-5686481)
0.527
2
UniProt:Q9NS37 ZHANG
0.527
2
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:Q9Y6H3 ATP23
0.527
2
UniProt:O75330-2 HMMR
0.527
2
UniProt:Q9BYX7 POTEKP
2
POTEKP [extracellular region]
(R-HSA-350725)
POTEKP [cytosol]
(R-HSA-350756)
0.527
2
UniProt:Q8N4N8 KIF2B
1
KIF2B [cytosol]
(R-HSA-376259)
0.527
2
UniProt:Q9NR55 BATF3
0.527
3
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.527
2
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