Reactome | DICER1 cleaves tRNA

DICER1 cleaves tRNA

Stable Identifier

R-HSA-9708292

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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DICER1 cleaves: tRNA Gln CTG in the D-loop, releasing a 19 nt fragment from the 5' end of the tRNA (Cole et al. 2009); tRNA Gly GCC, releasing a 22 nt fragment, tRF-3b (tRF-3027b), from the 3' end of the tRNA (Maute et al. 2013); precursor tRNA Ile TAT, releasing a 21 nt fragment, known as sRNA-Ile or miR-1983, from the 3' end of the tRNA (Hasler et al. 2016, and inferred from mouse homologs). Most tRFs are thought to arise in a DICER1 independent manner, however, as deletion of DICER1 does not significantly alter tRF expression (Kumar et al. 2014, Kuscu and Kumar et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
25270025	Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets Kumar, P, Anaya, J, Mudunuri, SB, Dutta, A	BMC Biol	2014
23297232	tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma Maute, RL, Schneider, C, Sumazin, P, Holmes, A, Califano, A, Basso, K, Dalla-Favera, R	Proc Natl Acad Sci U S A	2013
27345152	The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway Hasler, D, Lehmann, G, Murakawa, Y, Klironomos, F, Jakob, L, Grässer, FA, Rajewsky, N, Landthaler, M, Meister, G	Mol Cell	2016
29844106	tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner Kuscu, C, Kumar, P, Kiran, M, Su, Z, Malik, A, Dutta, A	RNA	2018
19850906	Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs Cole, C, Sobala, A, Lu, C, Thatcher, SR, Bowman, A, Brown, JW, Green, PJ, Barton, GJ, Hutvagner, G	RNA	2009