Reactome | HM13 [endoplasmic reticulum membrane]

HM13 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9708544

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

SPP

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15998642	Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 Steiner, H, Fluhrer, R, Haass, C, Haffner, C, Krawitz, P, Schmid, B	J Biol Chem	2005

External Reference Information

External Reference

UniProt:Q8TCT9 HM13

Gene Names

HM13, H13, IMP1, PSL3, SPP, MSTP086

Chain

chain:1-377

Reference Genes

BioGPS Gene:81502 HM13

COSMIC (genes):HM13 HM13

CTD Gene:81502 HM13

dbSNP Gene:81502 HM13

ENSEMBL:ENSG00000101294 HM13

ENSEMBL_homo_sapiens_GENE:ENSG00000101294.19 HM13

HGNC:16435 HM13

KEGG Gene (Homo sapiens):81502 HM13

Monarch:81502 HM13

NCBI Gene:81502 HM13

OMIM:607106 HM13

UCSC:Q8TCT9 HM13

Reference Transcript

Other Identifiers

11716646_a_at

11716647_x_at

11723016_a_at

11723017_x_at

11740470_x_at

224615_PM_x_at

224615_x_at

232209_PM_x_at

232209_x_at

3881288

3881289

3881290

3881291

3881295

3881299

3881308

3881324

3881326

3881327

3881329

3881332

3881335

3881336

3881340

3881348

3881349

3881350

3881353

3881354

3881355

3881356

3881357

49181_at

8061542

81502

A_23_P40347

A_33_P3323453

GE80775

GO:0001701

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0005791

GO:0005886

GO:0006465

GO:0006508

GO:0006886

GO:0008233

GO:0009986

GO:0016020

GO:0016787

GO:0030163

GO:0031625

GO:0033619

GO:0034599

GO:0036513

GO:0042500

GO:0042803

GO:0043226

GO:0048856

GO:0051604

GO:0098553

GO:0098554

GO:0140096

GO:1904211

HMNXSV003035869

HMNXSV003045343

Hs.306163.1.A1_3p_a_at

Hs.306163.2.A1_3p_x_at

Hs.87680.0.A1_3p_at

ILMN_1687833

ILMN_1807833

Inferred To

Hm13 [endoplasmic reticulum membrane] (Mus musculus)

Hm13 [endoplasmic reticulum membrane] (Rattus norvegicus)

Spp [endoplasmic reticulum membrane] (Drosophila melanogaster)

HM13 [endoplasmic reticulum membrane] (Bos taurus)

HM13 [endoplasmic reticulum membrane] (Canis familiaris)

HM13 [endoplasmic reticulum membrane] (Sus scrofa)

A0A1D5PUL3 [endoplasmic reticulum membrane] (Gallus gallus)

Cross References

RefSeq

NP_110416.1, NP_848696.1, NP_848697.1, NP_848695.1

OpenTargets

ENSG00000101294

GeneCards

Q8TCT9

HPA

ENSG00000101294-HM13

Ensembl

ENST00000340852, ENSP00000343032, ENSP00000501423, ENSP00000381237, ENST00000674240, ENST00000398174, ENSG00000101294

PRO

Q8TCT9

Pharos - Targets

Q8TCT9

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q8WU17 RNF139	1	RNF139 [endoplasmic reticulum membrane] (R-HSA-8861805)	0.524	2
UniProt:P17861-1 XBP1			0.524	2
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.524	6
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [azurophil granule membrane] (R-HSA-6800997)	0.508	2
UniProt:A0A0F6B5H5 A0A0F6B5H5			0.462	2
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2

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