Reactome | FBXL17 [nucleoplasm]

FBXL17 [nucleoplasm]

Stable Identifier

R-HSA-9708570

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UF56 FBXL17

Gene Names

FBXL17, FBL17, FBX13, FBXO13

Chain

chain:1-701

Reference Genes

BioGPS Gene:64839 FBXL17

COSMIC (genes):FBXL17 FBXL17

CTD Gene:64839 FBXL17

dbSNP Gene:64839 FBXL17

ENSEMBL:ENSG00000145743 FBXL17

HGNC:13615 FBXL17

KEGG:hsa:64839 FBXL17

Monarch:64839 FBXL17

NCBI Gene:64839 FBXL17

OMIM:609083 FBXL17

UCSC:Q9UF56 FBXL17

Reference Transcript

RefSeq:NM_001163315.2 FBXL17

Other Identifiers

11734075_a_at

11759124_at

11759125_at

16998700

227203_PM_at

227203_at

233087_PM_at

233087_at

242034_PM_at

242034_at

2870115

2870116

2870121

2870122

2870123

2870124

2870125

2870163

2870178

2870193

2870210

2870216

2870217

2870218

2870221

2870222

2870223

2870224

2870225

2870226

2870227

2870228

2870229

2870230

2870231

2870232

2870233

2870234

2870235

2870236

2870237

44481_at

59404_at

64839

8113445

A_23_P396322

A_32_P137632

A_32_P20288

A_33_P3314436

A_33_P3314441

GE578509

GE603245

GO:0000209

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006515

GO:0007399

GO:0008589

GO:0014033

GO:0016020

GO:0016567

GO:0019005

GO:0030154

GO:0030163

GO:0031146

GO:0043153

GO:0043161

GO:0043226

GO:0048856

HMNXSV003054937

HMNXSV003055457

Hs.118531.0.A1_3p_at

Hs.179112.0.A1_3p_at

Hs.272314.0.S1_3p_at

ILMN_1715901

PH_hs_0039894

TC05001660.hg

Participates

as an output of

FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)

as a component of

BACH1:FBXL17 [nucleoplasm] (Homo sapiens)

as an input of

FBXL17 binds BACH1:MAFK (Homo sapiens)

Inferred To

Skp2 [nucleoplasm] (Drosophila melanogaster)

Fbxl17 [nucleoplasm] (Mus musculus)

Ghost homologue of FBXL17 [nucleoplasm] (Rattus norvegicus)

skpt-1 [nucleoplasm] (Caenorhabditis elegans)

F1NKQ0 [nucleoplasm] (Gallus gallus)

FBXL17 [nucleoplasm] (Bos taurus)

FBXL17 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001156787.2

ENSEMBL

ENST00000542267, ENSP00000437464

OpenTargets

ENSG00000145743

HPA

ENSG00000145743-FBXL17

PRO

Q9UF56

Pharos - Targets

Q9UF56

GlyGen

Q9UF56

PDB

6WCQ, 6W66

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.737	16
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.643	7
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.643	6
UniProt:O14867 BACH1	5	BACH1 [nucleoplasm] (R-HSA-9707688) BACH1 [cytosol] (R-HSA-9708429) PolyUb-BACH1 [nucleoplasm] (R-HSA-9708486) p-Y483 BACH1 [nucleoplasm] (R-HSA-9762202) p-Y483 BACH1 [cytosol] (R-HSA-9762206)	0.643	5
UniProt:Q9UBP0-1 SPAST			0.602	4
UniProt:Q9P2J3 KLHL9	1	KLHL9 [cytosol] (R-HSA-976056)	0.597	8
UniProt:Q9UBP0 SPAST	1	SPAST [cytosol] (R-HSA-9668426)	0.591	3
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.558	11
UniProt:Q9P2G3 KLH14			0.527	3
UniProt:Q6JEL2 KLH10			0.527	3
UniProt:O95198 KLHL2	1	KLHL2 [cytosol] (R-HSA-8863217)	0.527	7
UniProt:Q6TDP4 KLH17			0.527	4
UniProt:Q9NXS3 KLH28			0.527	3
UniProt:Q9P2N7 KLHL13	1	KLHL13 [cytosol] (R-HSA-976041)	0.527	6
UniProt:Q99592 ZBT18			0.527	3
UniProt:B2RXF5 ZBT42			0.527	3
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	4
UniProt:Q86UZ6 ZBT46			0.527	2
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.527	5
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.527	8
UniProt:Q8NFY9 KBTBD8	1	KBTBD8 [cytosol] (R-HSA-8863192)	0.499	3
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.462	7

Cite Us!