Impaired BRCA2 binding to PALB2

Stable Identifier
R-HSA-9709603
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Impaired BRCA2 binding to PALB2
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This pathway describes BRCA2 missense mutations that affect the N-terminus of BRCA2 and impair the ability of BRCA2 to bind PALB2, which is a crucial step in homologous recombination repair (HRR) of DNA double-strand breaks (DSBs) (Xia et al. 2006).
Literature References
PubMed ID Title Journal Year
16793542 Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2

Xia, B, Sheng, Q, Nakanishi, K, Ohashi, A, Wu, J, Christ, N, Liu, X, Jasin, M, Couch, FJ, Livingston, DM

Mol Cell 2006
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
BioModels Database
Authored
Orlic-Milacic, M  (2020-12-11)
Reviewed
Liu, J  (2022-01-26)
Le, HP  (2022-01-26)
Heyer, WD  (2022-01-26)
Created
Orlic-Milacic, M  (2020-12-16)
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