CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9710835
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="36 37"Clathrin heavy chain 1, CLH1_HUMAN
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
12750159 ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma

Marynen, P, Simons, A, De Paepe, P, Stul, M, Baens, M, Speleman, F, Brons, P, Praet, M, Laureys, G, Poppe, B, Wlodarska, I, De Wolf-Peeters, C, Verhasselt, B, van Krieken, H, Vandenberghe, P

Blood 2003
External Reference Information
External Reference
UniProt:Q00610 CLTC
Gene Names
CLTC, CLH17, CLTCL2, KIAA0034
Chain
initiator methionine:, chain:2-1675
Reference Genes
COSMIC (genes):CLTC CLTC
dbSNP Gene:1213 CLTC
ENSEMBL:ENSG00000141367 CLTC
Participates
as a component of
Other forms of this molecule
CLTC [trans-Golgi network membrane]
CLTC [cytosol]
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol]
CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]
CLTC [endolysosome membrane]
CLTC [clathrin-coated endocytic vesicle membrane]
CLTC [lysosomal membrane]
CLTC [plasma membrane]
Modified Residues
Name
Insertion of residues 1058 to 1620 at 1635 from UniProt:Q9UM73 ALK
Coordinate
1635
Name
Replacement of residues 1634 to 1634 by YDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Interactors (12)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P32121 ARRB2  3 0.676 6
 UniProt:Q15398 DLGAP5  1 0.645 4
 UniProt:P13569 CFTR  17 0.615 21
 UniProt:P03372 ESR1  10 0.597 3
 UniProt:Q14164 IKBKE  5 0.589 2
 UniProt:P10636-8 MAPT  3 0.569 11
 UniProt:Q9NYZ3 GTSE1  4 0.564 3
 UniProt:Q13627 DYRK1A  1 0.547 2
 UniProt:O14920 IKBKB  3 0.536 2
 UniProt:Q96FJ0 STAMBPL1  1 0.527 2
 UniProt:P10242 MYB  1 0.499 4
 UniProt:P49407 ARRB1  6 0.491 3
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