Reactome | TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol]

TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol]

Stable Identifier

R-HSA-9710837

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tropomyosin alpha-3 chain, TPM3_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        TPM3(2-258)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)
        
        TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
10934142	TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors Lawrence, B, Perez-Atayde, A, Hibbard, MK, Rubin, BP, Dal Cin, P, Pinkus, JL, Pinkus, GS, Xiao, S, Yi, ES, Fletcher, CD, Fletcher, JA	Am J Pathol	2000
10216106	A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation Lamant, L, Dastugue, N, Pulford, K, Delsol, G, Mariamé, B	Blood	1999

External Reference Information

External Reference

UniProt:P06753 TPM3

Gene Names

TPM3

Chain

initiator methionine:1, chain:2-285, initiator methionine:1, initiator methionine:1

Reference Genes

BioGPS Gene:7170 TPM3

COSMIC (genes):TPM3 TPM3

CTD Gene:7170 TPM3

dbSNP Gene:7170 TPM3

ENSEMBL:ENSG00000143549 TPM3

HGNC:12012 TPM3

KEGG:hsa:7170 TPM3

Monarch:7170 TPM3

NCBI Gene:7170 TPM3

OMIM:191030 TPM3

UCSC:P06753 TPM3

Reference Transcript

Other Identifiers

11715666_a_at

11715667_s_at

11721289_at

11731455_at

11746919_a_at

11749935_s_at

11750045_x_at

214365_PM_at

214365_at

222976_3p_s_at

222976_PM_s_at

222976_s_at

224164_PM_at

224164_at

238065_PM_at

238065_at

238079_PM_at

238079_at

2436522

2436523

2436525

2436527

2436528

2436529

2436530

2436531

2436532

2436533

2436534

2436535

2436536

2436537

2436538

2436539

2436540

2436541

2436542

2436543

2436544

2436545

2436546

2436547

2436548

2436550

2436552

2436553

2436554

2436557

2436558

2436559

2436560

2436562

2436563

2436564

2436565

2436566

2436567

2436569

2436570

2436571

2436572

2436574

2436575

3069273

32754_at

3588684

3660774

3815587

3834246

3834250

43197_at

51351_at

55837_at

57840_at

7170

73377_at

75021_at

7920472

8142468

89615_at

A_23_P310222

A_23_P346086

A_24_P393880

A_32_P119197

A_33_P3223980

A_33_P3223990

A_33_P3346193

GE753797

GE84825

GE85555

GO:0001725

GO:0003012

GO:0003779

GO:0005515

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005862

GO:0005884

GO:0006936

GO:0007015

GO:0008092

GO:0015629

GO:0051015

GO:0070062

HMNXSV003000428

HMNXSV003018117

HMNXSV003038944

Hs.146070.0.A1_3p_at

Hs.169514.0.A1_3p_at

Hs.85844.3.S1_3p_at

ILMN_1660775

ILMN_1686388

ILMN_1697567

ILMN_1747696

PH_hs_0029336

PH_hs_0040951

X04201_at

g12653954_3p_a_at

g12653954_3p_s_at

g12653954_3p_x_at

g9508584_3p_at

Participates

as a component of

TPM3(2-258)-p-7Y ALK(1059-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol]

TPM3 [cytosol]

Modified Residues

Name

Insertion of residues 1059 to 1620 at 259 from UniProt:Q9UM73 ALK

Coordinate

259

Name

Replacement of residues 258 to 258 by EV

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
anaplastic large cell lymphoma	DOID:0050744
inflammatory myofibroblastic tumor	DOID:0050905

Cross References

RefSeq

NP_001351612.1, NP_001036818.1, NP_689476.2, NP_705935.1, NP_001036817.1, NP_001036816.1, NP_001265118.1, NP_001265120.1

OpenTargets

ENSG00000143549

ENSEMBL

ENSG00000143549, ENSP00000357517, ENSP00000357521, ENSP00000357520, ENST00000368531, ENSP00000357518, ENST00000341485, ENST00000368533, ENSP00000339035, ENST00000323144, ENSP00000341653, ENST00000328159, ENSP00000307712, ENSP00000498577, ENST00000330188, ENST00000651641, ENST00000302206

Mondo

0015798

HPA

ENSG00000143549-TPM3

GeneCards

TPM3

PRO

P06753

Pharos - Targets

P06753

Orphanet

TPM3

GlyGen

P06753

PDB

6OTN

HMDB Protein

HMDBP08072

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.849	10
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.735	7
UniProt:O14879 IFIT3	1	IFIT3 [cytosol] (R-HSA-947491)	0.696	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	14
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	2
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.564	4
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.556	3