EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol]

Stable Identifier
R-HSA-9710850
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Elongation factor 1-gamma, EF1G_HUMAN
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
28659337 Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene

Ferreiro, JF, Tousseyn, T, Uyttebroeck, A, Michaux, L, Devos, T, Cools, J, Geerdens, E, Jacobs, K, Wlodarska, I, Doms, K, Bempt, MV, van der Krogt, JA, Pierre, P, Vandenberghe, P, Pluys, U, Mentens, N

Haematologica 2017
External Reference Information
External Reference
UniProt:P26641 EEF1G
Gene Names
EEF1G, EF1G, PRO1608
Chain
initiator methionine:, chain:2-437
Reference Genes
COSMIC (genes):EEF1G EEF1G
dbSNP Gene:1937 EEF1G
ENSEMBL:ENSG00000254772 EEF1G
Participates
as a component of
Other forms of this molecule
EEF1G(1-343)-ALK(1106-1620) fusion [cytosol]
EEF1G [cytosol]
Modified Residues
Name
Insertion of residues 1106 to 1620 at 344 from UniProt:Q9UM73 ALK
Coordinate
344
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Interactors (28)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P24534 EEF1B2  1 0.885 12
 UniProt:P29692 EEF1D  1 0.813 8
 UniProt:P29692-2 EEF1D      0.666 4
 UniProt:Q05639 EEF1A2  1 0.643 5
 UniProt:P26640 VARS1  1 0.643 4
 UniProt:P10636-8 MAPT  3 0.643 5
 UniProt:P68104 EEF1A1  7 0.643 5
 UniProt:P13569 CFTR  17 0.615 14
 UniProt:P14679-2 P146792      0.556 3
 UniProt:P32497  1 0.556 3
 UniProt:P49090  1 0.556 3
 UniProt:Q9HB07 MYG1      0.556 3
 UniProt:P40560 YIA1      0.556 3
 UniProt:P32601 DSS4      0.556 3
 UniProt:P31930 UQCRC1  1 0.556 3
 UniProt:Q8WUW1 BRK1  1 0.556 3
 IntAct:EBI-25847655 CCSB      0.556 3
 UniProt:Q16512 PKN1  3 0.556 3
 UniProt:Q13011 ECH1  3 0.553 2
 UniProt:P00533 EGFR  20 0.553 2
 UniProt:P49589 CARS1  3 0.527 3
 UniProt:P48039 MTNR1A  1 0.527 2
 UniProt:P01106 MYC  2 0.527 2
 UniProt:Q5S007 LRRK2  1 0.527 3
 UniProt:Q9NPJ1 MKKS  1 0.527 2
 UniProt:O15357 INPPL1  1 0.527 3
 UniProt:Q969Q1 TRIM63  1 0.508 2
 UniProt:A0A096LP01 SIM26      0.462 2
Cite Us!