Reactome | APOE-4 [extracellular region]

APOE-4 [extracellular region]

Stable Identifier

R-HSA-9711070

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Apolipoprotein E isoform 4, APOE_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q3SYB3 FX4L6

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External Reference Information

External Reference

UniProt:P02649 APOE

Gene Names

APOE

Chain

signal peptide:1-18, chain:19-317

Reference Genes

COSMIC (genes):APOE APOE

dbSNP Gene:348 APOE

ENSEMBL:ENSG00000130203 APOE

Participates

as a component of

Amyloid fibrils [plasma membrane] (Homo sapiens)

as an input of

Amyloid fibrils have additional components (Homo sapiens)

Other forms of this molecule

APOE [endoplasmic reticulum lumen]

p-APOE [endoplasmic reticulum lumen]

APOE [extracellular region]

APOE [endocytic vesicle lumen]

APOE [plasma membrane]

APOE [clathrin-coated endocytic vesicle membrane]

APOE [endosome membrane]

APOE [endosome lumen]

APOE [early endosome]

Modified Residues

Name

L-cysteine 112 replaced with L-arginine

Coordinate

112

PsiMod

L-cysteine removal [MOD:01635]

A protein modification that effectively removes or replaces an L-cysteine.

L-arginine residue [MOD:00011]

A protein modification that effectively converts a source amino acid residue to an L-arginine.

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.809	11
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.784	23
UniProt:P05067-PRO_0000000093 APP			0.75	4
ChEBI:28304 HEPARIN			0.733	8
UniProt:P01130 LDLR	4	LDLR [plasma membrane] (R-HSA-171053) LDLR [clathrin-coated endocytic vesicle membrane] (R-HSA-171105) LDLR [endosome membrane] (R-HSA-171127) LDLR [endolysosome membrane] (R-HSA-6784818)	0.71	4
UniProt:P00738 HP	7	HP [specific granule lumen] (R-HSA-6799622) HP [extracellular region] (R-HSA-6799677) HP [tertiary granule lumen] (R-HSA-6800879) 7xHC-HP(19-160) [extracellular region] (R-HSA-2168848) 5xHC-HP(162-406) [extracellular region] (R-HSA-2168875) 7xHC-HP(19-160) [endocytic vesicle lumen] (R-HSA-2230994) 5xHC-HP(162-406) [endocytic vesicle lumen] (R-HSA-2230973)	0.675	7
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.672	8
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.641	9
UniProt:Q9NZC2 TREM2	1	TREM2 [plasma membrane] (R-HSA-197664)	0.602	4
UniProt:O75069 TMCC2			0.593	5
ChEBI:241349 DIMYRISTOYLPHOSPHATIDYL CHOLINE			0.59	3
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.589	2
UniProt:P02748 C9	1	C9(22-559) [extracellular region] (R-HSA-173717)	0.564	2
UniProt:Q8TBC4 UBA3	2	UBA3 [cytosol] (R-HSA-947632) G76-NEDD8-C237-UBA3 [cytosol] (R-HSA-8951640)	0.556	3
UniProt:Q9HBG4 ATP6V0A4	2	ATP6V0A4 [phagocytic vesicle membrane] (R-HSA-1222302) ATP6V0A4 [endosome membrane] (R-HSA-912605)	0.556	3
UniProt:P11137-4 MAP2			0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:Q3SYB3 FX4L6			0.556	3
UniProt:Q9NUB4 CT141			0.556	3
UniProt:Q6PID6 TTC33			0.556	3
UniProt:P10636-6 MAPT			0.556	3
UniProt:Q9Y3D2 MSRB2	1	MSRB2 [cytosol] (R-HSA-5676906)	0.556	3
UniProt:Q8IUW6 Q8IUW6			0.556	3
IntAct:EBI-25832170 ORF			0.556	3
UniProt:Q13829 TNFAIP1	1	TNFAIP1 [cytosol] (R-HSA-9696531)	0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
UniProt:Q14114-3 Q141143			0.556	3
UniProt:Q9NS23-4 RASSF1			0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:P26441 CNTF	1	CNTF [extracellular region] (R-HSA-5696441)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:P02795 MT2A	1	MT2A [cytosol] (R-HSA-1031707)	0.556	3
UniProt:Q9UIJ7 AK3	1	AK3 [mitochondrial matrix] (R-HSA-1008241)	0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:Q8WTV0-2 SCARB1	2	SCARB1-2 [endocytic vesicle membrane] (R-HSA-2512788) SCARB1-2 [plasma membrane] (R-HSA-349415)	0.556	3
UniProt:Q9H816 DCLRE1B	1	DCLRE1B [nucleoplasm] (R-HSA-6785735)	0.556	3
UniProt:O75409 HYPM			0.556	3
UniProt:Q8IY40 Q8IY40			0.556	3
IntAct:EBI-25832355 CCSB			0.556	3
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.556	3
UniProt:P17028 ZNF24			0.556	3
UniProt:Q9H6J7-2 CSTPP1			0.556	3
UniProt:Q9NYH9 UTP6	1	UTP6 [nucleoplasm] (R-HSA-6790674)	0.556	3
UniProt:Q9Y6C2-2 EMILIN1			0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:P27958-PRO_0000037570			0.537	4
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.527	7
UniProt:P09238 MMP10	2	MMP10(18-476) [extracellular region] (R-HSA-1604748) MMP10 [extracellular region] (R-HSA-1442488)	0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:Q13201 MMRN1	2	MMRN1(20-1228) [extracellular region] (R-HSA-114635) MMRN1(20-1228) [platelet alpha granule lumen] (R-HSA-114634)	0.527	2
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667)	0.527	2
UniProt:P02655 APOC2	3	APOC2 [early endosome] (R-HSA-2429686) APOC2 [cytosol] (R-HSA-2404145) APOC2 [extracellular region] (R-HSA-174699)	0.527	2
UniProt:P08254 MMP3	6	MMP3(100-477) [extracellular region] (R-HSA-1430778) MMP3 [extracellular region] (R-HSA-8943665) MMP3(18-477) [extracellular region] (R-HSA-1604707) MMP3(55-477) [extracellular region] (R-HSA-1604735) MMP3(18-54) [extracellular region] (R-HSA-1604705) MMP3(55-99) [extracellular region] (R-HSA-1604687)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.524	4
UniProt:Q9UBD9 CLCF1	1	CLCF1 [extracellular region] (R-HSA-5693175)	0.524	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.482	3
UniProt:P50502 ST13	1	ST13 [cytosol] (R-HSA-5255410)	0.482	3
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.482	3