Reactome | Cellular response to chemical stress

Cellular response to chemical stress

Stable Identifier

R-HSA-9711123

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Cells are equipped with versatile physiological stress responses to prevent hazardous consequences resulting from exposure to chemical insults of endogenous and exogenous origin. Even at equitoxic doses, different stressors induce distinctive and complex signaling cascades. The responses typically follow cell perturbations at the subcellular organelle level.

Expression of heme oxygenase 1 (HMOX1) is regulated by various indicators of cell stress. Cytoprotection by HMOX1 is exerted directly by HMOX1 and by the antioxidant metabolites it produces through the degradation of heme (Origassa et al, 2013; Ryter et al, 2006).

Reactive oxygen and nitrogen species (RONS) are important mediators of chemical stress, as they are produced endogenously in mitochondria, and also result from redox activities of many toxins and heavy metal cations. The points of RONS action in the cell are plasma and ER membrane lipids, as well as DNA, both acting as sensors for the cellular response. On the other hand, chemotherapeutic agents exert their action via generation of RONS and induction of cancer cell apoptosis, while drug resistance associates with RONS-induced cancer cell survival (Sampadi et al, 2020; Moldogazieva et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
28230817	Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies Vesela, E, Chroma, K, Mistrik, M, Turi, Z	Biomolecules	2017
24179613	Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury Câmara, N, Origassa, C	World journal of hepatology	2013
32189037	Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action Olsen, JV, Sampadi, B, Munk, S, Mullenders, LHF, van de Water, B, de Groot, AJ, Pines, A, Vrieling, H, Mišovic, B	Arch Toxicol	2020
30644759	Chemical activation of estrogen and aryl hydrocarbon receptor signaling pathways and their interaction in toxicology and metabolism Luch, A, Tarnow, P, Tralau, T	Expert Opin Drug Metab Toxicol	2019
22515967	Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies Jennings, P, Wiesinger, M, Lukas, A, Mayer, B	Toxicol In Vitro	2012
16601269	Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications Alam, J, Choi, AM, Ryter, SW	Physiol Rev	2006
30327380	Reactive Oxygen and Nitrogen Species-Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy Terentiev, AA, Lutsenko, SV, Moldogazieva, NT	Cancer Res	2018
20840865	Oxidative stress, inflammation, and cancer: how are they linked? Gupta, SC, Chaturvedi, MM, Aggarwal, BB, Reuter, S	Free Radic Biol Med	2010