HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol]

Stable Identifier
R-HSA-9711956
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Huntingtin-interacting protein 1, HIP1_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
25393796 Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib

Azada, M, Klempner, SJ, Schrock, AB, Ali, SM, Ou, SH, Stephens, PJ, Miller, VA, Ross, JS, Greenbowe, JR

J Thorac Oncol 2014
External Reference Information
External Reference
Gene Names
HIP1
Chain
chain:1-1037
Other Identifiers
11734760_at
11734761_a_at
11734762_at
11734763_at
11759141_at
17058826
205425_PM_at
205425_at
205426_PM_s_at
205426_s_at
226364_PM_at
226364_at
3057369
3057371
3057372
3057373
3057374
3057375
3057376
3057377
3057378
3057379
3057380
3057382
3057383
3057384
3057385
3057386
3057387
3057389
3057390
3057391
3057392
3057393
3057394
3057395
3057396
3057397
3057398
3057399
3057400
3057402
3057404
3057406
3057408
3057410
3057411
3057412
3057413
3057414
3057415
3057416
3057417
3057421
3057426
3057427
3092
41061_at
51980_at
8140319
A_23_P71033
A_24_P363548
A_24_P55391
A_24_P916314
GE60472
GO:0003779
GO:0005154
GO:0005198
GO:0005200
GO:0005515
GO:0005543
GO:0005634
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0006897
GO:0006915
GO:0006919
GO:0007010
GO:0007015
GO:0008092
GO:0008289
GO:0012501
GO:0012505
GO:0016020
GO:0016192
GO:0023052
GO:0030100
GO:0030136
GO:0030154
GO:0030276
GO:0030665
GO:0031410
GO:0032051
GO:0032266
GO:0035091
GO:0035254
GO:0035612
GO:0035615
GO:0042734
GO:0042803
GO:0042981
GO:0043226
GO:0043231
GO:0043325
GO:0045211
GO:0045742
GO:0046982
GO:0048260
GO:0048268
GO:0050821
GO:0051015
GO:0051897
GO:0060090
GO:0065003
GO:0080025
GO:0097190
GO:0098685
GO:0098793
GO:0098794
GO:0098978
GO:0099149
GO:0099171
GO:0099637
GO:2000588
HMNXSV003010981
Hs.38489.0.A1_3p_at
ILMN_1701403
PH_hs_0030302
TC07001534.hg
U79734_at
g12545385_3p_at
g2072422_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1058 to 1620 at 1020 from UniProt:Q9UM73 ALK
Coordinate
1020
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
lung adenocarcinoma DOID:3910 nonsmall cell adenocarcinoma
Interactors (13)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P42858 HTT  1 0.806 7
 UniProt:Q13573 SNW1  1 0.556 3
 UniProt:Q13901 C1D  1 0.556 3
 UniProt:Q08426 EHHADH  2 0.556 3
 UniProt:Q09028 RBBP4  1 0.556 3
 UniProt:Q9H0Y0 ATG10  2 0.556 3
 UniProt:Q86US8 SMG6  1 0.556 3
 UniProt:Q9NQ88 TIGAR  1 0.556 3
 UniProt:P35222 CTNNB1  20 0.556 3
 UniProt:Q06547-3 GABPB1  1 0.556 3
 UniProt:Q14032 BAAT  2 0.556 3
 UniProt:P10636-8 MAPT  3 0.527 4
 UniProt:O14641 DVL2  5 0.488 2
Cite Us!