Reactome | HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol]

HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9711975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Huntingtin-interacting protein 1, HIP1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        HIP1(1-963)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
        
        HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
24496003	HIP1-ALK, a novel ALK fusion variant that responds to crizotinib Fang, DD, Zhang, B, Gu, Q, Lira, M, Xu, Q, Sun, H, Qian, M, Sheng, W, Ozeck, M, Wang, Z, Zhang, C, Chen, X, Chen, KX, Li, J, Chen, SH, Christensen, J, Mao, M, Chan, CC	J Thorac Oncol	2014

External Reference Information

External Reference

UniProt:O00291 HIP1

Gene Names

HIP1

Chain

chain:1-1037

Reference Genes

BioGPS Gene:3092 HIP1

COSMIC (genes):HIP1 HIP1

CTD Gene:3092 HIP1

dbSNP Gene:3092 HIP1

ENSEMBL:ENSG00000127946 HIP1

HGNC:4913 HIP1

KEGG:hsa:3092 HIP1

Monarch:3092 HIP1

NCBI Entrez Gene:3092 HIP1

OMIM:601767 HIP1

UCSC:O00291 HIP1

Reference Transcript

Other Identifiers

11734760_at

11734761_a_at

11734762_at

11734763_at

11759141_at

11760599_at

1560317_PM_s_at

1560317_s_at

17058826

205425_PM_at

205425_at

205426_PM_s_at

205426_s_at

226364_PM_at

226364_at

3057369

3057371

3057372

3057373

3057374

3057375

3057376

3057377

3057378

3057379

3057380

3057382

3057383

3057384

3057385

3057386

3057387

3057389

3057390

3057391

3057392

3057393

3057394

3057395

3057396

3057397

3057398

3057399

3057400

3057402

3057404

3057406

3057408

3057409

3057410

3057411

3057412

3057413

3057414

3057415

3057416

3057417

3057421

3057422

3057426

3057427

3057500

3057501

3057502

3057504

3092

41061_at

51980_at

73956_at

8140319

8140356

A_23_P71033

A_24_P363548

A_24_P55391

A_24_P916314

A_24_P934455

A_33_P3343485

GE60472

GO:0003779

GO:0005154

GO:0005198

GO:0005200

GO:0005515

GO:0005543

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0005856

GO:0006897

GO:0006915

GO:0007015

GO:0008092

GO:0012505

GO:0016020

GO:0016192

GO:0030100

GO:0030136

GO:0030154

GO:0030276

GO:0030665

GO:0030864

GO:0031410

GO:0032051

GO:0032266

GO:0035091

GO:0035254

GO:0035612

GO:0035615

GO:0042803

GO:0042981

GO:0043325

GO:0045202

GO:0045742

GO:0046982

GO:0048260

GO:0048268

GO:0050821

GO:0051015

GO:0051897

GO:0060090

GO:0065003

GO:0080025

GO:0097190

GO:0098685

GO:0098793

GO:0098794

GO:0098978

GO:0099149

GO:0099171

GO:0099637

GO:2000588

HMNXSV003010981

HMNXSV003033539

Hs.38489.0.A1_3p_at

Hs2.420565.1.S1_3p_s_at

ILMN_1701403

PH_hs_0030302

TC07001534.hg

U79734_at

g12545385_3p_at

g2072422_3p_a_at

Participates

as a component of

HIP1(1-963)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol]

HIP1(1-1019)-ALK(1058-1620) [cytosol]

HIP1(1-963)-ALK(1058-1620) fusion [cytosol]

HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol]

HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol]

HIP1 [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 964 from UniProt:Q9UM73 ALK

Coordinate

964

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
lung squamous cell carcinoma	DOID:3907	squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung

Cross References

RefSeq

XP_011514418.1, NP_001230127.1, XP_005250361.1, XP_047276250.1, NP_001369374.1, NP_005329.3, XP_054214014.1, XP_054214016.1

COSMIC

COSF1620

OpenTargets

ENSG00000127946

ENSEMBL

ENSP00000410300, ENST00000434438, ENST00000616821, ENSP00000484528, ENST00000336926, ENSP00000336747, ENSG00000127946

Mondo

0005097

HPA

ENSG00000127946-HIP1

GeneCards

HIP1

PRO

O00291

Pharos - Targets

O00291

GlyGen

O00291

PDB

3I00, 2QA7, 2NO2

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.806	7
UniProt:Q86US8 SMG6	1	SMG6 [cytosol] (R-HSA-927851)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:Q13901 C1D	2	C1D [nucleoplasm] (R-HSA-6791515) C1D [nucleolus] (R-HSA-9935822)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.556	3
UniProt:Q9NQ88 TIGAR	1	TIGAR [cytosol] (R-HSA-5628829)	0.556	3
UniProt:Q14032 BAAT	2	BAAT [cytosol] (R-HSA-159392) BAAT [peroxisomal matrix] (R-HSA-193517)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	4
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.488	2