PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9713471
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cAMP-dependent protein kinase type I-alpha regulatory subunit, KAP0_HUMAN
Icon
PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] icon
PRKAR1A(1-183)-ALK(1058-1620) fusion [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
27245569 Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization

Ganesan, S, Hensing, T, Nowak, J, Ou, SH, Allen, J, Ross, JS, Wakelee, H, Schrock, AB, He, J, Zakowski, M, Frampton, GM, Gowen, K, Miller, VA, Menon, S, Chmielecki, J, Ladanyi, M, Molina, JR, Zauderer, M, Klempner, SJ, Peled, N, Firozvi, K, Ali, SM, Stephens, PJ, Fischbach, N, MacMahon, H, Lipson, D, Suh, JH, Sanford, E, Salgia, R, Elvin, JA, Chalmers, Z, Brahmer, JR, Yelensky, R, Kulkarni, A

Oncologist 2016
External Reference Information
External Reference
UniProt:P10644 PRKAR1A
Gene Names
PRKAR1A, PKR1, PRKAR1, TSE1
Chain
chain:1-381
Reference Genes
BioGPS Gene:5573 PRKAR1A
COSMIC (genes):PRKAR1A PRKAR1A
CTD Gene:5573 PRKAR1A
dbSNP Gene:5573 PRKAR1A
ENSEMBL:ENSG00000108946 PRKAR1A
ENSEMBL_homo_sapiens_GENE:ENSG00000108946.17 PRKAR1A
HGNC:9388 PRKAR1A
KEGG Gene (Homo sapiens):5573 PRKAR1A
Monarch:5573 PRKAR1A
NCBI Gene:5573 PRKAR1A
OMIM:188830 PRKAR1A
UCSC:P10644 PRKAR1A
Reference Transcript
Other Identifiers
11722007_a_at
11722008_a_at
11753791_s_at
16837326
200603_PM_at
200603_at
200604_PM_s_at
200604_s_at
200605_PM_s_at
200605_s_at
226_at
227_g_at
2346669
3732886
3732887
3732888
3732889
3732890
3732891
3732892
3732895
3732896
3732897
3732898
3732901
3732902
3732904
3732905
3732908
3732911
3732913
3732915
3732916
3732918
3732919
3732920
3732921
3732922
3732923
3732926
41768_at
54729_at
5573
60224_at
8009457
A_14_P136947
A_23_P433753
A_24_P245322
A_24_P356592
GE61216
GE87724
GO:0000166
GO:0001707
GO:0001772
GO:0001932
GO:0002376
GO:0003824
GO:0004862
GO:0005515
GO:0005737
GO:0005768
GO:0005771
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005929
GO:0005930
GO:0005952
GO:0006351
GO:0006355
GO:0006357
GO:0007010
GO:0007155
GO:0007189
GO:0007507
GO:0008603
GO:0010629
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019904
GO:0023052
GO:0030154
GO:0030552
GO:0031410
GO:0031588
GO:0031594
GO:0031625
GO:0032024
GO:0032991
GO:0034236
GO:0035556
GO:0036211
GO:0043226
GO:0044853
GO:0045202
GO:0045214
GO:0046007
GO:0048856
GO:0060038
GO:0071377
GO:0097224
GO:0097546
GO:0098772
GO:0098978
GO:2000480
HMNXSV003015567
HMNXSV003028511
HMNXSV003035036
Hs.183037.0.A3_3p_at
ILMN_1738632
ILMN_2277077
ILMN_2389590
M33336_at
TC17000804.hg
TC17002330.hg
TC17002331.hg
g1526988_3p_a_at
g4506062_3p_a_at
Participates
as a candidate of
as a component of
Other forms of this molecule
PRKAR1A(1-183)-p-7Y-ALK(1058-1620) fusion [cytosol]
PRKAR1A [ciliary base]
PRKAR1A [cytosol]
Modified Residues
Name
Insertion of residues 1058 to 1620 at 184 from UniProt:Q9UM73 ALK
Coordinate
184
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
HPA
GeneCards
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
HMDB Protein
Interactors (10)
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