Reactome | VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]

VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9713472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Vinculin, VINC_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ALK in cancer (Homo sapiens)
    - Signaling by ALK fusions and activated point mutants (Homo sapiens)
      - Autophosphorylation of ALK fusions (Homo sapiens)
        
        p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
        
        VCL(1-811)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
        
        VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
21076462	Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum Debelenko, LV, Raimondi, SC, Daw, N, Shivakumar, BR, Huang, D, Nelson, M, Bridge, JA	Mod Pathol	2011
21213368	ALK rearrangement in sickle cell trait-associated renal medullary carcinoma Mariño-Enríquez, A, Ou, WB, Weldon, CB, Fletcher, JA, Pérez-Atayde, AR	Genes Chromosomes Cancer	2011

External Reference Information

External Reference

UniProt:P18206 VCL

Gene Names

VCL

Chain

chain:1-1134

Reference Genes

BioGPS Gene:7414 VCL

COSMIC (genes):VCL VCL

CTD Gene:7414 VCL

dbSNP Gene:7414 VCL

ENSEMBL:ENSG00000035403 VCL

HGNC:12665 VCL

KEGG:hsa:7414 VCL

Monarch:7414 VCL

NCBI Gene:7414 VCL

OMIM:193065 VCL

UCSC:P18206 VCL

Reference Transcript

Participates

as a component of

VCL(1-811)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

VCL [cytosol]

VCL [specific granule lumen]

VCL [extracellular region]

VCL [secretory granule lumen]

VCL [ficolin-1-rich granule lumen]

VCL(95 kDa) [cytosol]

VCL(1-811)-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 812 from UniProt:Q9UM73 ALK

Coordinate

812

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
renal cell carcinoma	DOID:4450	RCC, adenocarcinoma of kidney, hypernephroma

Cross References

RefSeq

NP_003364.1, NP_054706.1

COSMIC

COSF1056

OpenTargets

ENSG00000035403

ENSEMBL

ENST00000372755, ENSP00000361841, ENSP00000211998, ENSG00000035403, ENST00000211998

Mondo

0005086

HPA

ENSG00000035403-VCL

GeneCards

VCL

PRO

P18206

Pharos - Targets

P18206

Orphanet

VCL

GlyGen

P18206

PDB

4EHP, 3S90, 5O2Q, 1RKE, 4LNP, 1RKC, 3RF3, 5L0C, 5L0D, 5L0I, 5L0J, 5L0G, 5L0H, 2GWW, 5L0F, 3MYI, 4PR9, 7KTW, 7KTU, 4DJ9, 6FUY, 7KTV, 7KTT, 6UPW, 3TJ6, 3VF0, 3TJ5, 3H2V, 4LN2, 1TR2, 3JBK, 2HSQ, 3H2U, 1YDI, 1SYQ, 2IBF

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18010 IPAA			0.758	7
UniProt:Q6XVZ2 Q6XVZ2			0.719	4
UniProt:B0BXR4 B0BXR4			0.65	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	9
UniProt:Q62417-2 SORBS1			0.591	3
UniProt:Q969V4 TEKT1			0.556	3
UniProt:Q15654 TRIP6			0.553	2
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.553	3
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-27-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783176) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) RPS27A(1-76) [cytosol] (R-HSA-939205) p-S65-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834951) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834993) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-63-RPS27A(1-76) [plasma membrane] (R-HSA-939855)	0.527	2
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.527	2
UniProt:Q7Z4L5 TTC21B	2	TTC21B [ciliary tip] (R-HSA-5625349) TTC21B [cilium] (R-HSA-5610430)	0.508	2

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