PPM1B(2-282)-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9713477
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein phosphatase 1B ecNumber3.1.3.16/ecNumber, PPM1B_HUMAN
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
27245569 Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization

Ganesan, S, Hensing, T, Nowak, J, Ou, SH, Allen, J, Ross, JS, Wakelee, H, Schrock, AB, He, J, Zakowski, M, Frampton, GM, Gowen, K, Miller, VA, Menon, S, Chmielecki, J, Ladanyi, M, Molina, JR, Zauderer, M, Klempner, SJ, Peled, N, Firozvi, K, Ali, SM, Stephens, PJ, Fischbach, N, MacMahon, H, Lipson, D, Suh, JH, Sanford, E, Salgia, R, Elvin, JA, Chalmers, Z, Brahmer, JR, Yelensky, R, Kulkarni, A

Oncologist 2016
External Reference Information
External Reference
UniProt:O75688 PPM1B
Gene Names
PPM1B, PP2CB
Chain
initiator methionine:, chain:2-479
Reference Genes
BioGPS Gene:5495 PPM1B
COSMIC (genes):PPM1B PPM1B
CTD Gene:5495 PPM1B
dbSNP Gene:5495 PPM1B
ENSEMBL:ENSG00000138032 PPM1B
HGNC:9276 PPM1B
KEGG:hsa:5495 PPM1B
Monarch:5495 PPM1B
NCBI Gene:5495 PPM1B
OMIM:603770 PPM1B
UCSC:O75688 PPM1B
Reference Transcript
Participates
as a candidate of
as a component of
Other forms of this molecule
PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol]
PPM1B [cytosol]
Modified Residues
Name
Insertion of residues 1058 to 1620 at 283 from UniProt:Q9UM73 ALK
Coordinate
283
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
ENSEMBL
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ZINC - Predictions - Purchasable
HMDB Protein
Interactors (5)
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