Reactome | SENP1 [cytosol]

SENP1 [cytosol]

Stable Identifier

R-HSA-9715128

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOF GTPase cycle (Homo sapiens)
        
        RHOF binds effectors at the plasma membrane (Homo sapiens)
        
        RHOF effectors [cytosol] (Homo sapiens)
        
        SENP1 [cytosol] (Homo sapiens)
        
        RHOF:GTP:RHOF effectors [plasma membrane] (Homo sapiens)
        
        RHOF effectors [cytosol] (Homo sapiens)
        
        SENP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P0U3 SENP1

Gene Names

SENP1

Chain

chain:1-644

Reference Genes

BioGPS Gene:29843 SENP1

COSMIC (genes):SENP1 SENP1

CTD Gene:29843 SENP1

dbSNP Gene:29843 SENP1

ENSEMBL:ENSG00000079387 SENP1

HGNC:17927 SENP1

KEGG:hsa:29843 SENP1

Monarch:29843 SENP1

NCBI Gene:29843 SENP1

OMIM:612157 SENP1

UCSC:Q9P0U3 SENP1

Reference Transcript

Other Identifiers

11739940_a_at

11739941_s_at

11764136_at

1552812_PM_a_at

1552812_a_at

16763853

226619_PM_at

226619_at

29843

3452964

3452965

3452967

3452969

3452971

3452972

3452973

3452974

3452975

3452977

3452979

3452980

3452987

3452988

3452989

3452990

3452991

3452992

3452993

3452994

3452995

3452996

3452998

3452999

3453000

3453001

3453002

3453003

3453004

3453006

3453008

3453009

3453010

3453011

3453013

3453014

3453015

3453016

3453017

3453019

3453020

3453021

3453022

64891_at

66230_at

7962760

A_23_P204536

A_24_P167412

A_33_P3304528

GE483673

GE81939

GO:0003824

GO:0004175

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005925

GO:0006355

GO:0006508

GO:0006919

GO:0008234

GO:0016787

GO:0016925

GO:0016926

GO:0016929

GO:0031965

GO:0043226

GO:0043488

GO:0045944

GO:0070139

GO:0097190

GO:0098978

GO:0140096

GO:0150052

HMNXSV003032392

Hs.66450.0.S2_3p_at

Hs2.66450.1.S1_3p_s_at

PH_hs_0024495

TC12001443.hg

Participates

as a candidate of

RHOF effectors [cytosol] (Homo sapiens)

Other forms of this molecule

SENP1 [nucleoplasm]

Inferred To

Ulp1 [cytosol] (Drosophila melanogaster)

SENP1 [cytosol] (Bos taurus)

SENP1 [cytosol] (Canis familiaris)

SENP1 [cytosol] (Gallus gallus)

SENP1 [cytosol] (Sus scrofa)

Senp1 [cytosol] (Mus musculus)

Senp1 [cytosol] (Rattus norvegicus)

senp1 [cytosol] (Xenopus tropicalis)

ulp-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001254523.1, NP_001254524.1

Guide to Pharmacology - Targets

2414

ENSEMBL

ENST00000549518, ENSP00000450076, ENST00000448372, ENST00000549595, ENSP00000394791, ENSP00000447328

OpenTargets

ENSG00000079387

HPA

ENSG00000079387-SENP1

ZINC - Substances

SENP1_HUMAN

ZINC target

Q9P0U3

PRO

Q9P0U3

Pharos - Targets

Q9P0U3

ZINC - Predictions - Purchasable

SENP1_HUMAN

PDB

2IYD, 2CKH, 2IYC, 2IY1, 2XPH, 2XRE, 2IY0, 2CKG, 2G4D, 6NNQ

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.87	12
UniProt:P61956 SUMO2	6	lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm] (R-HSA-9761546) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) SUMO2 [nucleoplasm] (R-HSA-2984281) lysyl-G93-SUMO2 [cytosol] (R-HSA-9834803) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618) SUMO2(1-95) [nucleoplasm] (R-HSA-2990837)	0.743	6
UniProt:P46060 RANGAP1	3	RANGAP1 [cytosol] (R-HSA-376255) RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416)	0.591	4