Reactome | HNRNPC [cytosol]

HNRNPC [cytosol]

Stable Identifier

R-HSA-9715136

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07910 HNRNPC

Gene Names

HNRNPC, HNRPC

Chain

initiator methionine:, chain:2-306

Reference Genes

BioGPS Gene:3183 HNRNPC

COSMIC (genes):HNRNPC HNRNPC

CTD Gene:3183 HNRNPC

dbSNP Gene:3183 HNRNPC

ENSEMBL:ENSG00000092199 HNRNPC

ENSEMBL_homo_sapiens_GENE:ENSG00000092199.19 HNRNPC

HGNC:5035 HNRNPC

KEGG Gene (Homo sapiens):3183 HNRNPC

Monarch:3183 HNRNPC

NCBI Gene:3183 HNRNPC

OMIM:164020 HNRNPC

UCSC:P07910 HNRNPC

Reference Transcript

Other Identifiers

11732246_a_at

11732247_s_at

11756337_x_at

11758144_x_at

1568941_3p_a_at

1568941_PM_a_at

1568941_a_at

16653739

16653741

16653743

16653745

16653747

18671138

18671144

18671145

18671146

18671147

18671148

18671149

200014_PM_s_at

200014_s_at

200751_PM_s_at

200751_s_at

212626_PM_x_at

212626_x_at

214737_3p_x_at

214737_PM_x_at

214737_x_at

227110_PM_at

227110_at

2520052

2520055

2520056

2520057

3183

32408_s_at

3343617

33666_at

3384883

3555883

3555884

3555885

3555886

3555887

3555888

3555889

3555891

3555893

3555896

3555897

3555898

3555903

3555905

3555906

3555907

3555908

3555909

3555922

3555923

3555924

3555925

3555926

3555927

3555928

3555932

3556310

3556312

3556314

3556316

3556318

3556320

3556322

3648218

723_s_at

7892621

7892865

7892979

7893081

7893196

7893325

7893460

7894042

7894045

7894107

7894110

7894294

7894404

7894439

7894595

7894914

7894953

7895062

7895404

7895571

7895574

7896007

7896256

7896423

7977657

8047059

A_23_P163006

A_32_P142028

A_33_P3294017

GE61328

GO:0000398

GO:0000785

GO:0001649

GO:0003676

GO:0003677

GO:0003723

GO:0003730

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005681

GO:0005694

GO:0005697

GO:0005829

GO:0005856

GO:0006325

GO:0006338

GO:0006397

GO:0008266

GO:0008380

GO:0015629

GO:0016020

GO:0016071

GO:0030154

GO:0031492

GO:0032200

GO:0032211

GO:0032991

GO:0042802

GO:0043226

GO:0070034

GO:0070062

GO:0070935

GO:0071013

GO:1990247

GO:1990904

HMNXSV003005460

Hs.182447.0.A1_3p_a_at

Hs.182447.0.A1_3p_x_at

Hs.182447.1.A1_3p_x_at

Hs.182447.2.A1_3p_at

Hs.182447.3.A1_3p_a_at

Hs2.250158.1.S1_3p_at

Hs2.250158.1.S1_3p_s_at

ILMN_2334587

M16342_at

PH_hs_0030525

TC14000915.hg

g4758543_3p_a_at

Participates

as a candidate of

Other forms of this molecule

SUMO1-K250-HNRNPC [nucleoplasm]

HNRNPC [nucleoplasm]

Inferred To

CG18656 [cytosol] (Drosophila melanogaster)

HNRPC [cytosol] (Bos taurus)

Hnrnpc [cytosol] (Mus musculus)

Hnrnpc [cytosol] (Rattus norvegicus)

HNRNPC [cytosol] (Sus scrofa)

LOC119869089 [cytosol] (Canis familiaris)

hnrnpc [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016876742.1, XP_011535011.1, NP_001070910.1, NP_004491.2, XP_006720188.1, XP_011535014.1, NP_112604.2, NP_001070911.1, XP_016876741.1, XP_011535013.1, XP_011535012.1, XP_011535010.1

OpenTargets

ENSG00000092199

HPA

ENSG00000092199-HNRNPC

GeneCards

P07910

Ensembl

ENST00000556628, ENSP00000451652, ENSP00000450629, ENSP00000450725, ENSP00000452276, ENSP00000451176, ENST00000554455, ENST00000557201, ENST00000554969, ENST00000555883, ENSP00000450544, ENST00000430246, ENSP00000451291, ENST00000556897, ENSP00000442816, ENSG00000092199, ENSP00000404848, ENST00000420743, ENST00000553300

PRO

P07910

Pharos - Targets

P07910

PDB

2MXY, 1WF2, 3LN4, 1TXP, 2MZ1

Interactors (102)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.863	8
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.845	7
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.834	8
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.792	5
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.749	5
UniProt:Q86SE5 RALYL			0.742	7
UniProt:Q9UKM9 RALY			0.742	5
UniProt:Q96IZ5 RBM41			0.742	5
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.731	4
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	6
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.718	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	18
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.706	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	7
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.666	4
UniProt:B2RXH8 HNRC2			0.666	4
UniProt:O60812 HNRC1			0.666	6
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.65	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.643	5
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.64	3
UniProt:O60506 HNRPQ			0.615	3
UniProt:Q53F19 NCBP3			0.615	4
UniProt:Q96KR1 ZFR			0.615	3
UniProt:Q96SI9 STRBP			0.615	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.615	3
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.615	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.615	6
UniProt:Q8IUH3 RBM45			0.597	3
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.597	4
UniProt:Q96QD9 FYTTD1	1	FYTTD1 [nucleoplasm] (R-HSA-8852176)	0.564	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.564	3
UniProt:Q9NQR1 KMT5A	1	SETD8 [nucleoplasm] (R-HSA-417142)	0.564	2
UniProt:Q6ZRY4 RBPS2			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q86SE5-3 RALYL			0.556	3
UniProt:Q13148 TADBP			0.556	3
UniProt:O15131 KPNA5	2	KPNA5 [nucleoplasm] (R-HSA-1176068) KPNA5 [cytosol] (R-HSA-1176062)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q53GL6 Q53GL6			0.556	3
UniProt:Q12929 EPS8	1	EPS8 [cytosol] (R-HSA-9662382)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q68DK2-5 ZFYVE26			0.556	3
UniProt:Q9NRI5-2 DISC1			0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:P38340 NTM1			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q14103 HNRNPD	1	HNRNPD [nucleoplasm] (R-HSA-71935)	0.547	3
UniProt:Q9Y618 NCOR2	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.536	2
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.536	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.536	3
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.536	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.527	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:P49761 CLK3			0.527	2
UniProt:Q9NZB2 F120A			0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.525	2
UniProt:Q92879 CELF1			0.519	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q9NYF8 BCLF1			0.483	2
UniProt:Q8WXF1 PSPC1			0.483	2
UniProt:O14979 HNRNPDL	1	HNRNPDL [cytosol] (R-HSA-8950323)	0.483	2
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.483	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.483	2
UniProt:Q13151 HNRNPA0	1	HNRNPA0 [nucleoplasm] (R-HSA-71925)	0.483	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.483	2
UniProt:Q1KMD3 HNRL2			0.483	2
UniProt:Q8IX01 SUGP2			0.483	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:Q8NEY8 PPHLN1	1	PPHLN1 [nucleoplasm] (R-HSA-9844032)	0.483	2
UniProt:Q86VM9 ZCH18			0.483	6
UniProt:Q9BQ04 RBM4B			0.483	2
UniProt:Q9BZJ0 CRNKL1	1	CRNKL1 [nucleoplasm] (R-HSA-8867899)	0.483	2
UniProt:Q13595 TRA2A			0.483	2
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.483	2
UniProt:Q14974 KPNB1	5	KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [cytosol] (R-HSA-180733)	0.483	2
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.483	2
UniProt:Q14151 SAFB2			0.483	2
UniProt:Q9NW64 RBM22	1	RBM22 [nucleoplasm] (R-HSA-5215975)	0.483	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.483	2
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.483	2
UniProt:O15226 NKRF			0.483	2
UniProt:O15504 NUP42	1	NUPL2 [cytosol] (R-HSA-157697)	0.483	2
UniProt:Q9NUL3 STAU2			0.483	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.483	2
UniProt:Q15003 NCAPH	3	p-T-NCAPH [cytosol] (R-HSA-2517885) p-S570-NCAPH [cytosol] (R-HSA-2529017) NCAPH [cytosol] (R-HSA-1638139)	0.483	2
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.483	2
UniProt:Q13285 NR5A1	3	NR5A1 [nucleoplasm] (R-HSA-452955) polySUMO2-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546383) monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546382)	0.483	2
UniProt:Q96DF8 ESS2			0.483	2
UniProt:Q6PJT7 ZC3HE			0.483	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.483	2
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.483	2
UniProt:O95758 PTBP3			0.483	2

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