RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9715284
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="34"E3 ubiquitin-protein ligase RNF213 ecNumber evidence="16"2.3.2.27/ecNumber ecNumber evidence="16"3.6.4.-/ecNumber, RN213_HUMAN
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
12112524 Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor

Cools, J, Wlodarska, I, Somers, R, Mentens, N, Pedeutour, F, Maes, B, De Wolf-Peeters, C, Pauwels, P, Hagemeijer, A, Marynen, P

Genes Chromosomes Cancer 2002
External Reference Information
External Reference
UniProt:Q63HN8 RNF213
Gene Names
RNF213, ALO17, C17orf27, KIAA1554, KIAA1618, MYSTR
Chain
chain:1-5207
Reference Genes
BioGPS Gene:57674 RNF213
COSMIC (genes):RNF213 RNF213
CTD Gene:57674 RNF213
dbSNP Gene:57674 RNF213
ENSEMBL:ENSG00000173821 RNF213
HGNC:14539 RNF213
KEGG:hsa:57674 RNF213
Monarch:57674 RNF213
NCBI Gene:57674 RNF213
OMIM:613768 RNF213
UCSC:Q63HN8 RNF213
Reference Transcript
Participates
as a member of
Other forms of this molecule
RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]
RNF213 [cytosol]
Modified Residues
Name
Insertion of residues 1058 to 1620 at 1173 from UniProt:Q9UM73 ALK
Coordinate
1173
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1359
Coordinate
1359
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Cross References
RefSeq
ENSEMBL
OpenTargets
Mondo
IntEnz
GeneCards
HPA
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (16)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O60939 SCN2B  1 0.643 3
 UniProt:P10321 HLA-C  8 0.564 2
 UniProt:Q86WC4 OSTM1  1 0.527 2
 UniProt:P34741 SDC2  20 0.527 2
 UniProt:O00526 UPK2      0.527 3
 UniProt:Q7LGA3 HS2ST1  1 0.527 2
 UniProt:P18031 PTPN1  2 0.527 2
 UniProt:P21462 FPR1  4 0.527 2
 UniProt:Q9NQ34 TMM9B      0.527 2
 UniProt:Q8N7X8 SIGL1      0.527 2
 UniProt:Q9Y279 VSIG4      0.527 2
 UniProt:Q9UQV4 LAMP3      0.527 2
 UniProt:Q9BZW8 CD244  1 0.527 2
 UniProt:Q13304 GPR17  1 0.527 2
 UniProt:Q14978 NOLC1      0.483 2
 UniProt:P05919 vpu  6 0.462 2
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