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p-Y254-RHOU [endosome membrane]
Stable Identifier
R-HSA-9726860
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
p-Y254-Wrch-1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOU GTPase cycle (Homo sapiens)
Phosphorylated RHOU translocates to the endosome membrane (Homo sapiens)
p-Y254-RHOU:GDP [endosome membrane] (Homo sapiens)
p-Y254-RHOU [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7L0Q8 RHOU
Gene Names
RHOU, ARHU, CDC42L1, G28K, WRCH1, SB128
Chain
chain:1-258
Reference Genes
BioGPS Gene:58480 RHOU
COSMIC (genes):RHOU RHOU
CTD Gene:58480 RHOU
dbSNP Gene:58480 RHOU
ENSEMBL:ENSG00000116574 RHOU
HGNC:17794 RHOU
Monarch:58480 RHOU
NCBI Gene:58480 RHOU
OMIM:606366 RHOU
UCSC:Q7L0Q8 RHOU
Reference Transcript
RefSeq:NM_021205.5 RHOU
Other Identifiers
11717416_a_at
11717417_s_at
16678518
223168_PM_at
223168_at
223169_PM_s_at
223169_s_at
2384410
2384411
2384412
2384413
2384414
2384420
2384421
2384422
2384423
45289_at
58480
7910387
91992_at
A_14_P201415
A_23_P114814
A_24_P62530
GE55805
GO:0000082
GO:0000139
GO:0002102
GO:0003824
GO:0003924
GO:0005085
GO:0005515
GO:0005525
GO:0005794
GO:0005829
GO:0005886
GO:0005925
GO:0006897
GO:0007010
GO:0007015
GO:0007163
GO:0007264
GO:0008360
GO:0010008
GO:0016192
GO:0016601
GO:0016787
GO:0019901
GO:0030036
GO:0032488
GO:0042995
GO:0043226
GO:0046872
GO:0051056
GO:0070161
GO:0098772
GO:1903955
HMNXSV003007370
Hs.20252.0.A2_3p_at
PH_hs_0001762
TC01006343.hg
g11527796_3p_a_at
p33650
Participates
as a component of
p-Y254-RHOU:GDP [endosome membrane] (Homo sapiens)
Other forms of this molecule
p-Y254-RHOU [plasma membrane]
RHOU [plasma membrane]
RHOU [cytosol]
Inferred To
phospho-rhoua [endosome membrane]
(Danio rerio)
phospho-RhoU [endosome membrane]
(Drosophila melanogaster)
phospho-rhou [endosome membrane]
(Xenopus tropicalis)
phospho-RHOU [endosome membrane]
(Canis familiaris)
phospho-RHOU [endosome membrane]
(Sus scrofa)
Homologues of p-Y254-RHOU [endosome membrane]
(Saccharomyces cerevisiae)
phospho-Rhou [endosome membrane]
(Rattus norvegicus)
phospho-p-Y254-RHOU [endosome membrane]
(Bos taurus)
phospho-p-Y254-RHOU [endosome membrane]
(Dictyostelium discoideum)
phospho-p-Y254-RHOU [endosome membrane]
(Gallus gallus)
phospho-p-Y254-RHOU [endosome membrane]
(Mus musculus)
phospho-p-Y254-RHOU [endosome membrane]
(Saccharomyces cerevisiae)
phospho-p-Y254-RHOU [endosome membrane]
(Schizosaccharomyces pombe)
phospho-chw-1 [endosome membrane]
(Caenorhabditis elegans)
Modified Residues
Name
O4'-phospho-L-tyrosine at 254
Coordinate
254
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
ENSEMBL
ENST00000366691
,
ENSP00000494673
,
ENST00000646945
,
ENSP00000355652
OpenTargets
ENSG00000116574
HPA
ENSG00000116574-RHOU
PRO
Q7L0Q8
Pharos - Targets
Q7L0Q8
HMDB Protein
HMDBP09122
PDB
2Q3H
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.787
6
UniProt:Q13153 PAK1
5
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
PAK1 [cytosol]
(R-HSA-162629)
Active PAK1 [cytosol]
(R-HSA-8964622)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [plasma membrane]
(R-HSA-3928409)
0.589
3
UniProt:Q14289 PTK2B
3
PTK2B [cytosol]
(R-HSA-390932)
PTK2B [cytosol]
(R-HSA-5218721)
p-Y-PTK2B [cytosol]
(R-HSA-508515)
0.581
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.524
3
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