SARS-CoV-2 N binds to TRIM25

Stable Identifier
R-HSA-9729437
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV-2 N binds to TRIM25
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Type I interferon (IFN-I) immune signaling is dampened in COVID-19, and SARS-CoV-2 nucleocapsid (N) protein produces this effect (Li et al, 2020). N co-localized and co-immunoprecipitated with TRIM25 (Gianni Gori Savellini et al. 2021; Oh & Shin 2021). Moreover, co-localization of RIG-I and TRIM25 was destroyed by co-expression of N protein. In summary, low-dose N protein suppressed IFN-I production via sequestering TRIM25 to inhibit RIG-I ubiquitination, while high-dose N protein promoted IFN-I signaling and inflammatory cytokine expression (Oh & Shin 2021; Zhao et al. 2021).
Literature References
PubMed ID Title Journal Year
34471099 A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

Hou, Z, Wang, W, Tan, G, Wang, G, Zhao, Y, Liu, Q, Yu, Y, Wu, P, Sui, L, Wang, Z

Signal Transduct Target Ther 2021
33801464 SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response

Shin, OS, Oh, SJ

Cells 2021
34452305 SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity

Cusi, MG, Anichini, G, Gandolfo, C, Gori Savellini, G

Viruses 2021
32589897 The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

Tan, YJ, Li, JY, Luo, R, Liao, CH, Qiu, Y, Ge, XY, Wang, Q

Virus Res 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-05-03)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-04-28)
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