Reactome | G3BP2 [cytosol]

G3BP2 [cytosol]

Stable Identifier

R-HSA-9729507

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ras GTPase-activating protein-binding protein 2, G3BP-2, GAP SH3 domain-binding protein 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds to G3BP1,G3BP2 (Homo sapiens)
        
        G3BP1,G3BP2 [cytosol] (Homo sapiens)
        
        G3BP2 [cytosol] (Homo sapiens)
        
        G3BP1,G3BP2:N [cytosol] (Homo sapiens)
        
        G3BP1,G3BP2 [cytosol] (Homo sapiens)
        
        G3BP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UN86 G3BP2

Gene Names

G3BP2, KIAA0660

Chain

initiator methionine:, chain:2-482

Reference Genes

BioGPS Gene:9908 G3BP2

COSMIC (genes):G3BP2 G3BP2

CTD Gene:9908 G3BP2

dbSNP Gene:9908 G3BP2

ENSEMBL:ENSG00000138757 G3BP2

ENSEMBL_homo_sapiens_GENE:ENSG00000138757.15 G3BP2

HGNC:30291 G3BP2

KEGG Gene (Homo sapiens):9908 G3BP2

Monarch:9908 G3BP2

NCBI Gene:9908 G3BP2

OMIM:620020 G3BP2

UCSC:Q9UN86 G3BP2

Reference Transcript

Other Identifiers

11716581_a_at

11716582_a_at

11727895_a_at

16976942

206383_PM_s_at

206383_s_at

208840_PM_s_at

208840_s_at

208841_PM_s_at

208841_s_at

2773757

2773758

2773759

2773760

2773761

2773762

2773763

2773764

2773765

2773769

2773770

2773772

2773773

2773774

2773777

2773780

2773781

2773782

2773783

2773784

2773785

2773786

2773789

2773795

2773796

2773797

35793_at

61402_at

67246_at

8101043

9908

A_23_P41255

A_24_P128977

A_24_P380132

GE53370

GE81782

GO:0002376

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0007253

GO:0007265

GO:0010494

GO:0023052

GO:0030159

GO:0034063

GO:0043226

GO:0043229

GO:0045087

GO:0051028

GO:0051260

GO:0060090

GO:0062029

GO:0065003

GO:0098542

GO:0140693

GO:1990904

HMNXSV003026405

Hs.6727.1.A1_3p_a_at

ILMN_1720422

ILMN_1759622

ILMN_2381753

ILMN_2381758

PH_hs_0023626

TC04002600.hg

g3327133_3p_a_at

g7110662_3p_a_at

Participates

as a member of

G3BP1,G3BP2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005263439.1, XP_016864367.1, XP_016864366.1, NP_987100.1, XP_011530743.1, NP_036429.2, NP_987101.1, XP_005263440.1, XP_016864368.1, XP_016864365.1

OpenTargets

ENSG00000138757

HPA

ENSG00000138757-G3BP2

GeneCards

Q9UN86

Ensembl

ENSP00000503911, ENSP00000504206, ENST00000678798, ENST00000677171, ENST00000678552, ENST00000677620, ENST00000678123, ENSP00000504101, ENSP00000504585, ENSP00000503228, ENSP00000503943, ENSP00000504588, ENST00000678273, ENSP00000503669, ENST00000679281, ENST00000678971, ENSP00000379069, ENSP00000504361, ENST00000677876, ENST00000677566, ENSP00000503442, ENSP00000504698, ENST00000677333, ENSP00000504363, ENST00000678100, ENSP00000503688, ENSP00000503209, ENSP00000504564, ENST00000677606, ENSP00000350518, ENSP00000504159, ENST00000677265, ENSP00000503239, ENSP00000352738, ENST00000677583, ENST00000676974, ENST00000678062, ENSP00000503504, ENSP00000503496, ENST00000678122, ENST00000395719, ENSP00000504025, ENSP00000504371, ENST00000676584, ENSP00000504316, ENST00000677201, ENSP00000504496, ENST00000676666, ENST00000678578, ENST00000359707, ENST00000677125, ENSG00000138757, ENST00000678265, ENSP00000502996, ENSP00000504591, ENST00000676470, ENSP00000504523, ENSP00000503355, ENST00000357854, ENST00000677162, ENST00000676839

PRO

Q9UN86

Pharos - Targets

Q9UN86

PDB

5DRV

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.969	37
UniProt:Q14694 USP10	3	USP10 [nucleoplasm] (R-HSA-3222218) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [cytosol] (R-HSA-6782974)	0.938	13
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.737	5
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	10
UniProt:P35658 NUP214	2	NUP214 [nucleoplasm] (R-HSA-451222) NUP214 [cytosol] (R-HSA-157691)	0.564	2
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.564	2
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.527	2
UniProt:P62847 RPS24	2	RPS24 [nucleoplasm] (R-HSA-6791186) RPS24 [cytosol] (R-HSA-72355)	0.527	2
UniProt:P46781 RPS9	2	RPS9 [nucleoplasm] (R-HSA-6790663) RPS9 [cytosol] (R-HSA-72387)	0.527	2
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.527	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.527	2
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.527	2

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