Reactome | G3BP2 [cytosol]

G3BP2 [cytosol]

Stable Identifier

R-HSA-9729507

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ras GTPase-activating protein-binding protein 2, G3BP-2, GAP SH3 domain-binding protein 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds to G3BP1,G3BP2 (Homo sapiens)
        
        G3BP1,G3BP2 [cytosol] (Homo sapiens)
        
        G3BP2 [cytosol] (Homo sapiens)
        
        G3BP1,G3BP2:N [cytosol] (Homo sapiens)
        
        G3BP1,G3BP2 [cytosol] (Homo sapiens)
        
        G3BP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UN86 G3BP2

Gene Names

G3BP2, KIAA0660

Chain

initiator methionine:, chain:2-482

Reference Genes

BioGPS Gene:9908 G3BP2

COSMIC (genes):G3BP2 G3BP2

CTD Gene:9908 G3BP2

dbSNP Gene:9908 G3BP2

ENSEMBL:ENSG00000138757 G3BP2

HGNC:30291 G3BP2

KEGG:hsa:9908 G3BP2

Monarch:9908 G3BP2

NCBI Gene:9908 G3BP2

OMIM:620020 G3BP2

UCSC:Q9UN86 G3BP2

Reference Transcript

Participates

as a member of

G3BP1,G3BP2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000138757

ENSEMBL

ENST00000678578, ENST00000678798, ENST00000678552, ENST00000678971, ENSG00000138757, ENST00000678273, ENSP00000503911, ENST00000676470, ENST00000676584, ENST00000677606, ENST00000677333, ENSP00000503355, ENSP00000504025, ENST00000395719, ENST00000677566, ENSP00000504564, ENST00000677620, ENSP00000503504, ENST00000677171, ENSP00000503496, ENSP00000502996, ENSP00000503943, ENST00000676666, ENST00000677876, ENSP00000504698, ENSP00000503442, ENSP00000504159, ENSP00000504496, ENSP00000379069, ENSP00000504371, ENSP00000504591, ENST00000677125, ENST00000677265, ENST00000677201, ENST00000677583, ENSP00000504361, ENST00000357854, ENST00000676839, ENSP00000504206, ENST00000678123, ENSP00000503239, ENST00000678100, ENST00000678122, ENST00000678265, ENSP00000504523, ENSP00000503209, ENSP00000504588, ENST00000676974, ENSP00000504101, ENSP00000504585, ENSP00000504363, ENSP00000503669, ENSP00000504316, ENSP00000503688, ENSP00000503228, ENST00000679281, ENST00000677162, ENSP00000350518, ENSP00000352738, ENST00000678062, ENST00000359707

GeneCards

G3BP2

HPA

ENSG00000138757-G3BP2

PRO

Q9UN86

Pharos - Targets

Q9UN86

GlyGen

Q9UN86

PDB

5DRV

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.969	37
UniProt:Q14694 USP10	3	USP10 [nucleoplasm] (R-HSA-3222218) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [cytosol] (R-HSA-6782974)	0.936	13
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.737	5
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	10
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.564	2
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.527	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.527	2
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.527	2
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:P35658 NUP214	2	NUP214 [nucleoplasm] (R-HSA-451222) NUP214 [cytosol] (R-HSA-157691)	0.527	2
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.527	2
UniProt:P62847 RPS24	2	RPS24 [cytosol] (R-HSA-72355) RPS24 [nucleoplasm] (R-HSA-6791186)	0.527	2

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