SARS-CoV-2 3a binds to UVRAG

Stable Identifier
R-HSA-9730505
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
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SARS-CoV-2 3a binds to UVRAG
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SARS-CoV-2 infection triggers an incomplete autophagy response in multiple cell lines. Expression of SARS-CoV-2 viroporin 3a (ORF3a) efficiently induces autophagosome formation by binding to UVRAG and triggering autophagy, but inhibiting the fusion between autophagosomes and lysosomes by disrupting the formation of the Beclin1:VSP34:UVRAG complex (Qu Y et al, 2020). Although 3a proteins are highly conserved between the SARS-CoV-1 and SARS-CoV-2, SARS-CoV-1 3a showed no effect on autophagy response (Qu Y et al, 2020).
Literature References
PubMed ID Title Journal Year
34386498 ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication

Liang, Q, Liu, C, Hu, G, Qu, Y, Zhang, Y, Li, J, Wang, W, Ren, S, Li, P, Wang, C, Liu, Z, Zhu, Y, Fu, J, Wang, Y, Wang, X, Zhang, R, Xiao, MZX

Front Cell Dev Biol 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-05-03)
Reviewed
Messina, F  (2022-02-18)
Created
Stephan, R  (2021-05-07)
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