SARS-CoV-1 6 binds to NMI

Stable Identifier
R-HSA-9731047
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
cytosol
ReviewStatus
5/5
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SARS-CoV-1 6 binds to NMI
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SARS-CoV-1 protein 6 binds to N-myc-interactor (NMI), a signaling pathway regulator involved in the innate immune system response (Cheng et al, 2015). NMI has been previously shown to be induced by IFN and to regulate IFN-dependent transcription (Zhu et al, 1999). Cheng et al also showed that protein 6 can promote the ubiquitin-dependent proteosomal degradation of NMI. It is unclear how exactly this happens and how much it contributes to suppression of the innate immune response in SARS.
Literature References
PubMed ID Title Journal Year
9989503 Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling

Zhu, M, John, S, Berg, M, Leonard, WJ

Cell 1999
25907116 Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor

Cheng, W, Chen, S, Li, R, Chen, Y, Wang, M, Guo, D

Virol Sin 2015
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Cross References
Mondo
Authored
Stephan, R  (2021-05-11)
Reviewed
D'Eustachio, P  (2021-01-26)
Created
Stephan, R  (2021-05-12)
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