SARS-CoV-1 3b binds to RUNX1

Stable Identifier
R-HSA-9731051
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human SARS coronavirus
Compartment
ReviewStatus
5/5
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SARS‑CoV‑1 3b, after translocating to the nucleus, binds to runt-related transcription factor 1 (RUNX1) and increases its promoting activity. RUNX1 plays a crucial role in development of myeloid and lymphoid lineage cells. Together with CBFB it forms core-binding factor (CBF), which further interacts with other transcription factors and co-activators or co-repressors on RUNX1 binding elements and regulates transcription of many target genes. 3b-dependent increase in the interleukin-2 (IL2) promoter activity relies on RUNX1b transcription factor complex binding. Additionally, 3b also affected its transactivation on the IL2 promoter by modulating phosphorylation levels of RUNX1b through ERK. Finally, 3b significantly enhances the RUNX1b transactivation potential on the endogenous CCL3 (MIP-1alpha) promoter (Varshney et al, 2012).
Literature References
PubMed ID Title Journal Year
22253733 SARS coronavirus 3b accessory protein modulates transcriptional activity of RUNX1b

Agnihotram, S, Tan, YJ, Agnihothram, S, Baric, R, Varshney, B, Lal, SK

PLoS One 2012
Participants
Participates
Disease
Name Identifier Synonyms
severe acute respiratory syndrome DOID:2945 SARS-CoV infection, SARS
Authored
Reviewed
Created
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