Reactome | ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine

ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine

Stable Identifier

R-HSA-9731661

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ADAL1 hydrolyzes N6-methyl-dAMP to dIMP and methylamine

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Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of N6-methyl-dAMP and water to form dIMP and methylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011). Scaletti et al. (2021) suggest that under physiological conditions this reaction could enable the detoxification and salvage of methylated adenosine nucleotides.

Literature References

PubMed ID	Title	Journal	Year
32144205	MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool Vallin, KS, Jemth, AS, Scaletti, ER, Stenmark, P, Helleday, T, Sarno, A, Warpman Berglund, U, Bräutigam, L	J Biol Chem	2020
21755941	Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates Furman, PA, Sofia, MJ, Du, J, Bao, H, Murakami, E, Mosley, RT	J Med Chem	2011