Reactome | Triazenes produce DNA damage in the form of O6-methylguanine

Triazenes produce DNA damage in the form of O6-methylguanine

Stable Identifier

R-HSA-9732692

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Triazenes produce DNA damage in the form of O6-methylguanine

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Monofunctional alkylating chemotherapeutic agents from the triazene family, dacarbazine (Souliotis et al. 1991), procarbazine (Souliotis et al. 1990), temozolomide (Taverna et al. 1992 - study done in mice) and streptozotocin (Bennett and Pegg 1981 - study done in rats), produce DNA damage in the form of O6-methylguanine (O6meG), which can be reversed by MGMT (6-O-methylguanine-DNA methyltransferase).

Literature References

PubMed ID	Title	Journal	Year
1421437	Influence of O6-methylguanine on DNA damage and cytotoxicity of temozolomide in L1210 mouse leukemia sensitive and resistant to chloroethylnitrosoureas Citti, L, Bonfanti, M, D'Incalci, M, Taverna, P, Catapano, CV	Anticancer Drugs	1992
2328502	Accumulation of O6-methylguanine in human blood leukocyte DNA during exposure to procarbazine and its relationships with dose and repair Boussiotis, VA, Souliotis, VL, Pangalis, GA, Kaila, S, Kyrtopoulos, SA	Cancer Res	1990
1704822	In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine Boussiotis, VA, Souliotis, VL, Pangalis, GA, Kyrtopoulos, SA	Carcinogenesis	1991