Reactome | ORC(1-5) [nucleoplasm]

ORC(1-5) [nucleoplasm]

Stable Identifier

R-HSA-9736362

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ORC1:ORC2:ORC3:ORC4:ATP:ORC5

Locations in the PathwayBrowser

Expand all

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
    - Assembly of the ORC complex at the origin of replication (Homo sapiens)
      - Formation of ORC(1-5) complex (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
      - Formation of ORC(1-6) complex (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
    - CDC6 association with the ORC:origin complex (Homo sapiens)
      - CDC6 association with ORC(1-6) at replication origins (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
    - CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
      - ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
    - CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)
      - ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
        
        ORC(1-5) [nucleoplasm] (Homo sapiens)

Participants

components

Participates

as a component of

ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)

Inferred To

ORC(1-5) [nucleoplasm] (Bos taurus)

ORC(1-5) [nucleoplasm] (Caenorhabditis elegans)

ORC(1-5) [nucleoplasm] (Canis familiaris)

ORC(1-5) [nucleoplasm] (Dictyostelium discoideum)

ORC(1-5) [nucleoplasm] (Drosophila melanogaster)

ORC(1-5) [nucleoplasm] (Gallus gallus)

ORC(1-5) [nucleoplasm] (Mus musculus)

ORC(1-5) [nucleoplasm] (Rattus norvegicus)

ORC(1-5) [nucleoplasm] (Saccharomyces cerevisiae)

ORC(1-5) [nucleoplasm] (Schizosaccharomyces pombe)

ORC(1-5) [nucleoplasm] (Sus scrofa)

ORC(1-5) [nucleoplasm] (Xenopus tropicalis)