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Drug ADME
Stable Identifier
R-HSA-9748784
Type
Pathway
Species
Homo sapiens
Synonyms
Drug Absorption, Distribution, Metabolism and Excretion (ADME), Metabolism and Transport of Drugs (ADME), Drug Pharmacokinetics (PK)
ReviewStatus
5/5
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Drug ADME (Homo sapiens)
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Pharmacokinetics (PK) is a branch of pharmacology dedicated to determining the chemical fate of substances in living organisms, from administration to elimination from the body. PK can be described as how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how a drug affects the organism. Both PK and PD are described for each drug annotated in the Drug Absorption, Distribution, Metabolism and Excretion (ADME) pathways. For example, although paracetamol ADME (PK) is described in this section, the pharmacological inhibition (PD) of its targets (PTGS1 and PTGS2) is described in the relevant pathway where these enzymes perform their physiological duties. A connection is made between the two pathways to link PK and PD annotations.
The disposition of a pharmaceutical compound within an organism can be described by four main stages; absorption, distribution, metabolism, and excretion, abbreviated to ADME (Pallasch 1988, Ruiz-Garcia et al. 2008, Currie 2018). Sometimes, separate steps can be tacked on to ADME depending on what is being described. For example, where a drug is released from a pharmaceutical formulation, liberation (L) is added to ADME (LADME) or where the toxicity of a compound is described, T is added (ADMET).
ADME of various drugs is annotated in this section.
Literature References
PubMed ID
Title
Journal
Year
17630642
Pharmacokinetics in drug discovery
Ruiz-Garcia, A
,
Casabo, VG
,
Moss, A
,
Bermejo, M
J Pharm Sci
2008
29724803
Pharmacology, Part 2: Introduction to Pharmacokinetics
Currie, GM
J Nucl Med Technol
2018
3046441
Principles of pharmacotherapy: II. Pharmacokinetics
Pallasch, TJ
Anesth Prog
1988
Participants
Events
Azathioprine ADME
(Homo sapiens)
Aspirin ADME
(Homo sapiens)
Paracetamol ADME
(Homo sapiens)
Abacavir ADME
(Homo sapiens)
Atorvastatin ADME
(Homo sapiens)
Ribavirin ADME
(Homo sapiens)
Prednisone ADME
(Homo sapiens)
Ciprofloxacin ADME
(Homo sapiens)
Event Information
Go Biological Process
xenobiotic metabolic process (0006805)
Orthologous Events
Drug ADME (Bos taurus)
Drug ADME (Caenorhabditis elegans)
Drug ADME (Canis familiaris)
Drug ADME (Danio rerio)
Drug ADME (Dictyostelium discoideum)
Drug ADME (Drosophila melanogaster)
Drug ADME (Gallus gallus)
Drug ADME (Mus musculus)
Drug ADME (Plasmodium falciparum)
Drug ADME (Rattus norvegicus)
Drug ADME (Saccharomyces cerevisiae)
Drug ADME (Schizosaccharomyces pombe)
Drug ADME (Sus scrofa)
Drug ADME (Xenopus tropicalis)
Authored
Jassal, B (2021-07-27)
Reviewed
D'Eustachio, P (2021-09-23)
Created
Jassal, B (2021-07-27)
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