XDH oxidises 6MP to 6TU

Stable Identifier
R-HSA-9748991
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
6MP--XDH-->6TU
ReviewStatus
5/5
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6-mercaptopurine (6MP) can be metabolized via three competing pathways; oxidation by xanthine oxidase (XDH), methylation by thiopurine methyl S-transferase (TPMT) and conversion by hypoxanthine-guanine phosphoribosyltransferase (HPRT1).

6-mercaptopurine (6MP) is subjected to high first-pass metabolism due to oxidation in intestinal cells and liver cells by xanthine oxidase (XDH) (Saksela & Raivio 1996, Yamaguchi et al. 2007, Choughule et al. 2014). This reaction produces an inactive metabolite 6-thiouric acid (6TU, via 8-OH-6MP), which is excreted in urine. Patients with low XDH expression can exhibit elevated levels of the toxic antimetabolite 6MP which might result in a higher risk of thiopurine-induced adverse effects (Ding et al. 2021).
Participants
Participates
Event Information
Catalyst Activity

xanthine oxidase activity of XDH dimer [cytosol]

Orthologous Events
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